All about GBM
GBM is an aggressive brain tumor classified into what stage
Stage 4
The first initial symptom/concern of the patient was
Fatigue
Epidermal Growth Factor Receptor (EGFR) is functioning as an oncogene or tumor suppressor in GBM
Oncogene
The vast majority of GBM is hereditary or sporadic
Sporadic
Surgery cannot always be performed due to
An initial diagnostic test for GBM is
Magnetic Resonance Imaging (MRI)
Following chemotherapy and radiation, the patient began taking this medication
Oral Temozolomide (TMZ)
A possible treatment using TMZ targets this pathway
Sonic Hedgehog Pathway
This common mutated protein is found in glioblastomas
Epidermal Growth Factor Receptor (EGFR)
The fatigue and malaise were so significant that the patient thought he may have had which disease
COVID-19
Glioblastomas often express a mutant variant of EGFR which can constitutively activate which protein
Phosphoinositide 3-kinase (PI3K)
Name one of the four cell lineages GBM originates from
Neural stem cells (NSCs)
NSC-derived astrocytes
Oligodendrocyte precursor cells
Mesenchymal cells
The tumor biopsy yielded an infiltrating glioma with increased _______ activity and _______ proliferation
mitotic activity and vascular proliferation