Rezdiffra 101
What is the active ingredient in Rezdiffra
What is resmetirom?
A patient weighing less than 100 kg receives this daily dose
What is 80mg
The “S” in MASH stands for this
What is steatohepatitis
Name one common AE associated with Rezdiffra
What are diarrhea, nausea, pruritus, vomiting, constipation, abdominal pain or dizziness
AASLD guidance suggests that patients with suspected MASH should be risk-stratified using a stepwise approach that can begin with this commonly used blood-based test.
What is a FIB-4?
Rezdiffra selectively activates this receptor
What is thyroid hormone receptor-beta (THR-B)
Rezdiffra can be taken without this
What is food
This is the strongest predictor of severe liver-related consequences
What is fibrosis
Rezdiffra carries a warning for this potentially serious liver-related adverse event
What is hepatotoxicity
When identifying candidates for Resmetirom what VCTE range are good patients to put on therapy?
What is 8kpa-15kpa
MAESTRO-NASH evaluated histologic efficacy at this time point
What is Week 52/Month 12?
THR-B signaling dysfunction in the liver worsens this
What is fibrosis progression
How prevalent is MASH in patients with type 2 diabetes?
What is 1 in 3 patients with type 2 diabetes have MASH
If an acute gallbladder event such as acute cholecystitis is suspected, the PI recommends temporarily doing what?
What is interrupt Rezdiffra until the event is resolved
This is not routinely recommended for the staging of MASH
What is liver biopsy
Rezdiffra is indicated for MASH patients with fibrosis but not patients with this condition.
What is cirrhosis
Rezdiffra works to improve lipid metabolism and reduces these two things
what is inflammation and fibrosis
How prevalent is MASH in patients with obesity?
What is 1 in 3 patients with obesity have MASH
how many more patients taking Rezdiffra had fibrosis improvement with no worsening of steatohepatitis at week 52 when compared with placebo?
What is 1.6-2x as many
Resmetirom treatment is not recommended for patients with ongoing alcohol consumption defined as?
What is for women greater than 20g per day and for men greater than 30g/day
True or false: Rezdiffra has a listed contraindication in the PI
What is false. There are no contraindications listed but it does have a limitation of use.
A patient weighing 85kg is taking clopidogrel. What Rezdiffra dose is recommended
What is 60mg once daily
Starting at F2 the risk of mortality increases this many times
What is 10-17x
How many more patients taking Rezdiffra achieved steatohepatitis resolution with no worsening of fibrosis at week 52 vs. placebo?
What is 2.4-3x as many
What testing does the AASLD recommend prior to starting Resmetirom?
Hepatic function panel, thyroid function panel, noninvasive measurement of liver stiffness