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Radiopharmaceuticals
Generators
MOL
RRx QC
RRx #2
100

What are radiopharmaceutical additives that prevent microbial or bacterial growth

Bacteriostatic agents. ex: Benzyl alcohol
100
What is the generator column made of?
Aluminum oxide
100
MOL used in V/Q studies
Capillary Blockade
100
What QC procedure checks for Mo99 in Tc99m eluate?
radionuclidic purity
100
How is Ga68 produced?

Generator (Ge-68/Ga-68 Generator)

200
What is the valence state of Technetium Pertechnetate
+7 Valence state
200
What is used to elude the generator?
0.9% NaCl
200
GI bleed MOL
Compartmental (leakage from compartment)
200
What is a radiochemical purity test looking for?
Technetium in any other form- HR or free tech
200
What is the trade name for Ga-68 Dotatate?
Netspot
300
What % of MDP dose is on the bone at 3 hours in a normal patient?
50-60%
300
After generator is eluded, how long does it take for Tc activity to build back up to maximum activity?
24 hours
300
Meckel's MOL
secretion
300
What do we use to perform radiochemical purity test?
Chromatography
300

What is the recommended dose in mCi to be administered for PET Imaging?

0.o54mCi/kg of body weight up to 5.4 mCi

400

What is the difference between a RRx and a radiochemical?

Radiopharmaceuticals have undergone extensive testing to be sterile, pyrogen-free, and safe for injecting. Radiochemicals have not.

400
What type of generator system is more efficient?
Dry
400
MOL useful in locating ectopic/accessory spleens using heat-damaged RBCs
Cell sequestration
400
How do we test Radionuclidic purity?
Moly breakthrough test using dose calibrator
400
When did Ga68 Dotatate become FDA approved?
June 2016
500

What are 5 properties of an ideal diagnostic RRx?

Pure Gamma Emitter, short effective T1/2, High target-to-nontarget ratio, minimal radiation dose to pt and tech, inexpensive and readily available

500
A generator has a 93% elution efficiency. What is the eluate activity when there are 540mCi of technetium on the column.
502.2mCi
500

Fluoride ion diffuses into bone tissue and exchanges with hydroxide ion, an integral part of the hydroxyapatite structure, to form fluoroapatite. Binding is essentially irreversible. What does this describe?

Exchange diffusion
500
What is the limit of aluminum oxide that can be in Tc99m eluate when performing a chemical purity test?
10ppm or <10 ug/mL
500

positron emitting analogue of somatostatin?

Ga68 Dotatate