Topic 12_Intracellular Compartments and Protein Sorting I
Organelle that contains ribosomes on its outer surface and functions in protein processing
What is the Rough ER?
This amino acid sequence on a protein prevents it from moving out of the endoplasmic reticulum (ER)
What is the ER retention signal?
This type of protein plays a significant role in the development of COPII vesicles.
What is Sar1 protein?
This type of biomolecular condensate is located within a chloroplast and participates in carbon fixation from CO2 in algae.
What is Pyrenoid?
Compartments in eukaryotic cells that concentrate biomolecules like proteins and nucleic acids, but lack a surrounding membrane
What are Biomolecular Condensates?
This ER-Resident chaperone protein is a member of the hsp-70 type chaperones
What is BiP?
This enzyme moves phospholipids at random between leaflets of the membrane
What is scramblase
What is phosphatidylcholine
Signal sequence responsible for translocation of all proteins to the ER
What is the ER Signal Sequence?
This protein must contain one or more sugars or oligosaccharide change covalently linked to amino acid side chains
What is a glycoprotein
Group of proteins that facilitate the formation of vesicles to transport newly synthesized proteins in the forward direction from the ER to the cis-Golgi complex
What are Coat Protein Complex II proteins?
Small monomeric GTPases that function as key regulators of eukaryotic membrane trafficking via budding, transport, docking, and fusion of lipid bilayer vesicles
What are RAB proteins?
Ribonucleoprotein particle responsible for targeting of signal-bearing proteins to the ER for secretion or membrane insertion
What is the Signal Recognition Particle (SRP)?
This is the process of transferring either a single saccharide or a performed precursor oligosaccharide to proteins
What is protein glycosylation?
This adaptor molecule that recruits clathrin molecules binds to the tail of LDL receptors during the receptor-mediated endocytosis of cholesterol.
What is adaptin?
These receptors mediate export from the nucleus by recognizing proteins bearing export sequences and also mediate nuclear localization signal-dependent nuclear import by recognizing import sequences.
What are karyopherins?
Membrane protein complex that forms transmembrane channel allowing proteins to be translocated across and integrated into the ER membrane
What is SEC61 Translocator?
This carbohydrate-binding chaperone protein is in the ER and binds to oligosaccharides on completely folded proteins and retains them in the ER.
What is Calnexin?
Fusion of vesicles from the same compartment
What is homotropic fusion?
A coated vesicle used in the retrieval pathway from Endosome and Golgi
What is a Retromer?