Meet me at the A&P
This is the name of the region in the bladder between the ureter and urethral openings.
What is the Trigone?
A Renal FNA is composed exclusively of macrophages (typically from a cystic lesion).
This would be the most prudent diagnosis.
What is Non-diagnostic?
Unless it is determined to be a benign cyst on radiography, an RCC cannot be excluded because some RCCs can be cystic.
You are screening an instrumented urine specimen; you are not surprised when you see this purple, amorphous contaminant?
What is Lubricant?
This test may be used to triage an indeterminate result of AUC.
What is FISH?
These cells with ample granular cytoplasm are characteristic of this benign neoplasm, but other differentials should be ruled out.
What is an Oncocytoma?
You see UCC in a Kidney wash. The cancer is originating from this part of the kidney.
What is the renal pelvis?
This is important factor to consider when interpreting a kidney FNA.
If a specimen is this - be cautious to not over diagnose it as positive.
What is Cellularity of the specimen?
What is a Hypocellular specimen?
Oncocytoma and Chromophobe RCC typically have ample cytoplasm. This type of tubular cells may be a differential.
(First, think - what are the two types of tubular cells?)
What are Proximal tubular cells
This distinct variant of RCC comprises 3-5% of all RCCs and is associated with numerous chromosomal monosomies. It's prognosis is very favorable.
What is Chromophobe RCC?
This unevenly distributed, highly cellular, benign globular structure mimics the papillae of LG Papillary RCC.
(The arrow is pointing to a characteristic feature of the larger structure.)
What is a Glomerulus?
Pt. hx notes prostatic hyperplasia. Within a concerning cell cluster, you notice yellow-brown granules in the cytoplasm of these cells.
What are Seminal Vesicle cells?
Several types of casts can be seen in urinary specimens. These casts can indicate organ rejection following a kidney transplant.
Degenerated renal tubule casts and white blood cell casts? Also, necrotic debris may be seen.
Low-Grade Clear Cell RCC or Papillary RCC have scant to moderate amounts of cytoplasm
This type of tubule cell may be a reasonable diagnostic differential.
What are Distal Tubular Cells?
This type of RCC is associated with deletions on the short arm of chromosome 3 - this is the location of the VHL gene.
What is Clear cell RCC?
When present in large numbers, these cercariform cells in are characteristic of this malignant lesion.
What is UCC?
A sample from this type of specimen reveals abundant degenerated enteric cells - often resembling macrophages.
What is an illeal conduit specimen / neobladder?
Kidney FNAs are relatively uncommon. The following can cause errors in dx. What type of errors might they cause?
Xanthrogranulomatous pyelonephritis, angiomyolipoma, hepatocytes, tubular cells, glomeruli, urothelial cells, or adrenal cortical cells.
What are false-positive results?
UroVysion combines centromeric probes to these three chromosomes and a locus-specific probe to this band?
What multitarget assay combines centromeric probes to chromosomes 3, 7 and 17, with a locus specific probe to 9p21?
This can appear mass-like on radiography. It exhibits necrosis and can contain rare atypical cells that can easily be confused with Clear Cell RCC. The abundance of acute inflammation and paucity of atypia should help your diagnosis.
What is a Renal Abcess?
This table in CIBAS is an excellent one to study.