GU Malignancy Jeopardy

Testicular Cancer

100

What is the most common presentation of testicular cancer?

A painless testicular mass

200

What is the initial imaging for a suspected testicular cancer?

Bilateral trans-scrotal ultrasound with doppler

300

Where is the most common first location for testicular cancer to spread to?

Retroperitoneum 

400

What stage is a testicular cancer that has spread to the lung?

Stage III

500

Part 1: Which two tumor markers can be elevated in testicular cancer?

Part 2: What other cancer also gives off one of these markers? 

Part 1: HCG and AFP

Part 2: Liver Cancer or a Hepatic Tumor (AFP)

Renal Cell Carcinoma and Prostate Cancer

100

What is the major driving force in prostate cancer?

Androgens are the major driving force in prostate Cancer

200

What is the most common type of Renal Cell Carcinoma (pathology)?

Clear Call Carcinoma is the most common type of Renal Cell Carcinoma

300

Name two risk factors for Renal Cell Carcinoma?

Cigarette smoking, end-stage renal failure, hypertension and obesity are risk factors for RCC

400

What is the classic triad of Renal Cell Carcinoma?

The classic triad of RCC flank pain, hematuria and flank mass (but in less than 10% of patients).

500

Part 1: What is the most common site of metastatic disease in prostate cancer?

Part 2 BONUS: What drugs can be used to prevent skeletal fractures in a patient with bone disease from prostate cancer?

Part 1: Bone is the most common site of metastatic disease in prostate cancer

Part 2: IV Bisphosphonates

Wilms Tumor

100

What is the common age for a Wilm's tumor? 

Ages 2-5

200

About what percentage of patients present with hypertension with a new Dx of Wilms? 

25% of patients with Wilms tumor will present with HTN

300

How do most patients with Wilms tumor present?

Increasing abdominal size or Incidentally noted abdominal mass

400

Name two late effects from the treatment (chemotherapy) of Wilm's tumor

Late effects of chemotherapy from Wilms: 

Infertility, renal insufficiency, leukemia, neuro psychiatric abnormalities

500

Part 1: What percentage of patients will have metastatic disease at the time of diagnosis? 

Part 2: Where is the most common first location of metastatic disease?

Part 1: 10% of patients will have metastatic disease t the time of a Wilms tumor diagnosis

Part 2: Lung (chest)

Penile and Bladder Cancer

100

The major risk factor for bladder cancer is?

Smoking is the major risk factor for bladder cancer

200

Name two risk factors for penile cancer

Poor hygiene, phimosis, increased number of sexual partners, HPV infection, exposure to tobacco products are risk factors for penile cancer

300

What is the most common presentation of bladder cancer?

Painless hemituria is the most common presentation

400

What is the stage of a penile cancer that has a TNM of T1,N1, M0? 

Stage III penile cancer 

500

Name 2 treatments for penile cancer

Treatments for penile cancer include: Penectomy, Topical treatments (fluorouracil) radiotherapy, Mohs surgery, circumcision and laser ablation

Grab Bag

100

What is the second most common cancer in men?

Prostate Cancer

200

The BRCA 1/2 gene increases the risk of which cancer in males?

Prostate Cancer is higher in carriers of the BRCA 1/2 gene (as well as breast, pancreatic and ovarian cancer)

300

Crypto-orchism is a risk factor for which malignancy

Testicular Cancer

400

Penile cancer is associated with which virus and what prophylactic measures can be taken?

HPV is the most common virus associated with penile cancer. Gardasil vaccine protects against the two most common strains of HPV that increase cancer risk (strain 16 and 18) 

500

What is the Karnofsky score is a patient who is able to care for them self but cannot do normal activities?

70 is the Karnofsy score