Trial By Design
Presented in tandem at SGO 2023, these trials established immunotherapy as a new standard of care for advanced or recurrent endometrial cancer
If an itis develops while on pembrolizumab, these agents are considered the gold standard to control a raging immune system
Steroids
Although it offers no therapeutic benefit to clear active infections or treat existing cervical dysplasia, CDC guidelines still recommend administering this to eligible patients with an abnormal Pap or positive high-risk HPV result to protect against other strains they have not yet acquired
What is a gardasil vaccine
After a prolonged period of negative trials using immunotherapy in ovarian cancer, this trial established what new regimen for platinum resistant ovarian cancer? (Trial name and regimen please)
Keynote B96 - paclitaxel with pembrolizumab +/- bevacizumab
Pneumonitis
A cancer patient receiving Enhertu presents with progressive dyspnea and lower extremity edema. An echocardiogram reveals an absolute decrease in LVEF of 12% from baseline to under 50%. This toxic effect requires withholding the drug.
What is HER2-inhibitor-induced cardiotoxicity (or left ventricular dysfunction / heart failure)?
Avutometinib and defactinib combination therapy for low-grade serous ovarian cancer is FDA approved in the presence of these mutations
KRAS mutations
I didn't know trametinib would make me feel like a teenager again - what can you give me to manage my breakouts?!
Topical clindamycin with oral doxycycline
Often performed for malignant bowel obstruction or severe ascites in advanced ovarian cancer, this bedside or interventional radiology procedure uses a small tube to drain fluid or decompress the stomach for symptomatic relief without curative intent.
What is a venting gastrostomy
This trial combines a glucocoticoid receptor antagonist in combination with a special taxane, so avoid all steroid use please
ROSELLA - relacorilant with nab-paclitaxel
Alopecia is reported at 20-30% in trials use this class of targeted therapeutic agents?
Anti-body drug conjugates (ADCs)
To prevent radiation-induced vaginal stenosis and shortening following pelvic radiotherapy or brachytherapy, clinicians routinely prescribe this progressive set of tube-shaped medical devices to maintain tissue elasticity and vaginal caliber.
What are vaginal dilators
Speaking of low grade ovarian cancer, this trial recently showcased that chemotherapy followed by letrozole maintenance should be standard of care, unless you have no gross residual after surgery
You're old so your eye sight isn't great - but let me add these therapies to make sure we tip that vision right over the edge. (name at least 2 of us)
Mirvetuximab, tisotumab, trametinib, avutometinib/defactinib
Approved by the FDA as the first neurokinin 3 (NK3) receptor antagonist for non-hormonal management, this oral medication targets temperature-regulating neurons in the hypothalamus to reduce moderate-to-severe hot flashes.
What is veozah or fezolinetant