Boooooo-zy Science 👻
This microorganism converts sugar into alcohol in a process called fermentation
What is yeast?
This enzyme unwinds the DNA double helix during replication, separating the two strands.
What is a helicase?
This histological feature of MASH involves swollen, rounded hepatocytes with rarefied cytoplasm.
What is hepatocyte ballooning?
This actress earned a Ph.D. in neuroscience from UCLA before becoming famous on a TV show.
Who is Mayim Bialik?
This chemical is added to C. elegans plates to ward off spoooooky fungi.
What is nystatin?
This toxic alcohol can cause blindness when metabolized into formic acid.
What is methanol?
These repetitive DNA sequences at the ends of chromosomes shorten with successive rounds of cell division.
What are telomeres?
This hepatic cell type transforms into a collagen-producing myofibroblast-like cell during liver fibrosis.
What is a hepatic stellate cell?
This pioneering scientist was the first woman to win a Nobel Prize and remains the only person to win Nobel Prizes in two different scientific disciplines.
Who is Marie Curie?
This is an invisible assassin that sneaks into cell culture dishes and wreaks havoc.
What is mycoplasma?
Alcohol metabolism increases levels of this cofactor, whose accumulation inhibits fatty acid oxidation.
What is NADH?
These mobile genetic elements, sometimes called jumping genes, were first discovered by Barbara McClintock in maize.
What are transposons?
This transcriptional coactivator regulates mitochondrial biogenesis and oxidative metabolism and is frequently discussed in the context of metabolic liver disease.
What is PGC-1α?
This NASA astronaut became the first American woman in space in 1983.
Who is Sally Ride?
In the Hartman lab's first publication, we used what type of unusual worms?
What are tetraploid worms?
This medication causes unpleasant reactions to alcohol by inhibiting aldehyde dehydrogenase.
What is disulfiram?
This bromodomain-containing protein acts as a switch between transcription and DNA repair
What is BRD4?
This nuclear receptor regulates hepatic fatty acid oxidation during fasting and is activated by endogenous fatty acids and their derivatives.
What is PPARα?
Her X-ray diffraction images, including the famous Photo 51, provided critical evidence for the double-helical structure of DNA.
Who is Rosalind Franklin?
This is the year in which Dr. Hartman received her Ph.D.
What is 2016?
This alcohol-associated neurological syndrome is caused by thiamine deficiency and classically presents with confusion, ataxia, and eye movement abnormalities.
What is Wernicke encephalopathy?
CRISPR-Cas9 typically recognizes this short DNA sequence adjacent to its target before cutting the DNA.
What is the PAM (protospacer adjacent motif)?
This enzyme catalyzes the rate-limiting step of mitochondrial fatty acid β-oxidation by transferring long-chain acyl groups to carnitine.
What is CPT1?
This Canadian biochemist and physician helped establish the mathematical relationship between enzyme reaction velocity and substrate concentration in 1913.
Who is Maud Menten?
This is Joel Meyer's middle name.
What is Newman?