Black Box Warnings
What is at least 1 BBW of ibuprofen?
- CV thrombotic events
- GI bleeding, ulceration, or perforation
Wha nasal spray is indicated in opioid overdoses?
Naloxone (Narcan)
What is the most significant AE of acetaminophen?
hepatotoxicity
Name the Fab Five warfarin drug interactions!
fluconazole, amiodarone, Bactrim, fluoroquinolones, Flagyl
What antiglycemic agent has a BBW of lactic acidosis?
Metformin
What kind of animal bite may elevate a persons PT interval or INR?
Snake bite (more specifically north american pit viper)
What class of anti-hypertensives most commonly causes dry cough?
ACE inhibitors
What diabetes drugs should not be used in combination with GLP-1s due to risk of hypoglycemia?
insulin, sulfonylureas, meglitinides
Name 2 anti-hypertensive classes that have a BBW of pregnancy
ACE inhibitors, ARBs
What is the treatment for a tylenol (acetaminophen) overdose? (drug and routes)
N-acetylcysteine (NAC). Oral or IV
What diuretic can cause gynecomastia in males?
Spironolactone
What drug class can possibly cause serotonin syndrome when combined with dextromethorphan?
MAOis
What class of medications have a BBW for mortality?
JAK inhibitors
Should you give activated charcoal to someone who has ingested a button battery for decontamination?
NO
What serious, but rare adverse effect has been reported with GLP-1 receptor agonists?
These antibiotics can cause chelation when combined with calcium phosphate binders!
oral quinolones and oral tetracyclines
Name all four BBWs for amiodarone
life threatening arrhythmias, pulmonary toxicity, hepatotoxicity, pro-arrhythmic effects
Name 1 treatment for a b-blocker overdose (9 possible answers)
Atropine, IV fluids, Catecholamines, glucagon, high dose insulin, bicarbonate, calcium, and lipids
(also dialysis depending on what b-blocker)
What anti-arrhythmic can cause blue-gray skin discoloration with long term use?
Amiodarone
Name 3 very common CYP3A4 inducers and CYP3A4 inhibitors that interact with lots and lots of drugs.
inducers: phenytoin, carbamazepine, phenobarbital, rifampin, St. Johns Wort
inhibitors: azole antifungals, erythromycin, non-DHP CCBs, grapefruit juice, anti-HIV agents