Oropharynx
This drug is an EGFR blocker that is often used as an alternative to chemo in pts with poor tolerance.
What is cetuximab?
The 5 subsites of the supraglottis. Must name all 5
False vocal cords
Arytenoids
Ventricles
Epiglottis
Aryepiglottic folds
These sites should always be included in an intermediate dose for NPX volume.
6 sites to get credit
What is:
1. Entire NPX
2. parapharyngeal space+ Bilateral pterygoid fossa 3. Anterior ⅓ clivus (entire clivus if involved)
4. Nerve locations-including bilateral FO (V3) and FR (V2) and PPF
5. Inf sphenoid sinus
6. Posterior 1/3 of nasal cavity and maxillary sinuses
Location of the lingual tonsil
Where is the base of tongue?
Berniere and Cooper combined analysis demonstrated these features warrant concurrent chemo with PORT
What are positive margins and/or ECE?
The significantly different endpoint in ORATOR1.
Bonus-was it clinically meaningful
What is MDADI?
swallowing function
no it was not
This is included in a radical neck dissection
include nodal levels, nerves and vasculature removed
What are 1B-5, IJV and spinal accessory nerve?
Radiation treatment volumes and dose for widely metastatic NPX cancer
What is definitive dose RT to primary and regional LNs?
These are the 2 points required to measure DOI
What are basement membrane and deepest point?
The DAHANCA RT dosing option
What is 6fx a week?
Differences in MDADI on ORATOR-2
What is none?
Main difference was excessive deaths
These are 3 indications for boosting the stoma with PORT
What are
1. emergennt tracheostomy
2. subglottic extension
3. Anterior soft tissue extension
Situations 3 situations to electively cover 1B.
+1B LN does not count
What is:
1. level II with ENE or big node
2. oral cavity involvement
3. nasal cavity involvement
A 2.1 cm isolated ipsilateral LN with ECE is classified by this nodal stage.
What is N2a?
This defines stage T1 max sinus
What is nothing?
Tx primary only, lung mets have long natural history
The arms on HN005
What is
1) 70 Gy in 30fx with q3 cis
2) 60 Gy in 30fx with q3 cis
3) 60 Gy in 25fx with nivo
In HN cancer keynote 048 looked at PDL1 and surrounding micro environment to determine a combine prognostic score. This % and higher showed clear benefit, while below this number was unclear.
How much is 1%?
The best way to delineate if there's CNS invasion if it's not obvious.
What is the thin black line that represents corticol bone? How do I confirm with CT.
This is the rationale behind electively covering down to level IV in OC in node negative neck.
What are skip lesions?
This is the best sequence to look at early stage sinonasal?
Fluid enhances tumor doesn't
ECOG 33-11 had 3 risk stratifications. This group was randomized and defined by what criteria.
Must get them all
What is T1-T2 with negative or close margins (<3 mm), N1-N2 with <1mm ENE, or up to four positive nodes?
Per Yamazaki hypofx data for early glottic cancer this was the winning dosing and fractionation scheme for T1N0 glottic cancer.
What is 63 Gy in 28 fx (2.25 Gy/fx)?
In a meta-analysis by Claire Petit looking at different chemo sequencing options with RT including:
induction with tax, induction w/o tax, adjuvant chemo, and CRT only
This was the order by HR from most effective tx to least effective.
D'cruz randomized to elective v early salvage and showed worse OS (ss)in early stage T1-2N0 lateralized OC.
However during this time, stage was not the SOC factor that drove dissection.
This was. Name it.
What is DOI?
In Dutch NWHHT study on malignant salivary tumors which clinical feature showed greatest improvement from PORT?
What is T3/T4?
84% v 18% LC