Anemias
+ hemoglobinemia, + hemoglobinuria, + hemosiderin in urine, very low haptoglobin, +/- schistocytes
category of anemia?
What is intravascular hemolytic anemia?
patients with this disease lack factor VIII
What is hemophilia A?
First line treatment for ITP
Glucocorticoids (prednisone or dexamethasone)
FEVER, lymphadenopathy, bone pain, CNS symptoms. M/C in children age 3-7.
What is ALL?
spherocytes (3 answers!)
What is hereditary spherocytosis, autoimmune hemolytic anemia, and G6PD deficiency?
Sx: fatigue, headache, SOB, pica (ice), pallor, dark stools.
which diagnosis
What is iron deficiency anemia?
treatment for this disorder is factor IX infusion
What is Hemophilia B?
Pentad of: thrombocytopenia, anemia, fever, kidney disease, neurological findings
What is TTP?
Isolated lymphocytosis, smudge cells, m/c type of leukemia
What is CLL?
howell-jolly bodies and target cells
What is Sickle Cell Anemia?
increased MMA, increased homocysteine, decreased cobalamin, MCV >100
most likely cause
What is B12 deficiency?
This is the most common inherited bleeding disorder
What is Von Willebrand Disease?
normal platelet range
What is 150,000 - 450,000/uL?
associated with oncogene bcr-abl, translocation between q9 and q22
What is CML?
Auer rods on smear
What is AML?
X linked disorder, MC enzyme deficiency, induced by: infections, fava beans, dapsone, quinine, etc.
most likely disorder
What is G6PD Deficiency?
Green leafy vegetables could be helpful for patients with this deficiency
What is Vitamin K deficiency?
1. underproduction
2. non-immune mediated
3. immune mediated
these are causes of what?
What are three causes of thrombocytopenia?
can only arise from B cells and lymph node biopsy shows Reed-Sternberg cells
What is Hodgkin Lymphoma?
Pelger-Huet abnormality and ringed sideroblasts
What is myelodysplastic syndrome?
MC first presentation = dactylitis
which disease
Sickle cell anemia
Clinical presentation of bleeding at multiple sites, purprua fulminant, trousseau syndrome
What is DIC (disseminated intravascular coagulation)?
etiology of congenital or acquired deficiency or ADAMTS-13
What is TTP?
has association with viruses, presents with peripheral lymphadenopathy, fever, sweats, weight loss
What is Non-Hodgkin Lymphoma?
rouleaux formation on smear
What is plasma cell myeloma?