AML
Indolent Lymphomas
ALL
Multiple Myeloma
Burkitt's Lymphoma
100
In THIS condition, patient may have dyspnea, edema, fever, weight gain > 5kg, hypotension. You treated with dexamethasone 10mg q12h. You should have given prophylaxis : dexamethasone 2.5mg/m2 x 14 days of induction
What is Differentiation syndrome
100
APLES: Age over 60, Performance status >1, elevated LDH, Extranodal sites of disease > 1, and stage III or IV is a mneomonic to remember this.
What risk factors are considered when determining IPI?
100
This is the mechanism of action of inotuzumab ozogamicin.
What is a humanized CD22-directed monoclonal antibody-drug conjugate composed of the IgG4 kappa antibody inotuzumab which binds CD22, causing the complex to get internalized, and a calicheamicin component which is released and causes double-stranded DNA breaks?
100
This disease features a serum monoclonal protein < 3, clonal plasma cells in marrow < 10%, and no SLIM-CRAB features, so you're going to watch and wait.
What is MGUS?
100
This immunophenotype is seen with Burkitt's lymphoma and this is the "characteristic" histologic feature.
What is CD19+, CD20+, BCL6+, CD10+, Usually BCL2 negative, TDT negative?
What is a "starry sky appearance" due to macrophages ingesting apoptotic tumor cells?
200
You see this slide and decide on THIS therapy.
What is ATRA?
200
This is the most common translocation in mantle cell lymphoma
What is t(11;14)(q13;q32), resulting in overexpression of the CCND1 (cyclin D1) gene?
200
This is the Immunophenotype of B-ALL/LBL
Whati is : positive CD19, CD79a, cytoplasmic CD22. Most lymphoblasts are positive for CD10, CD24, PAX5, Tdt; CD13 or CD33 can be seen with certain categories of B-ALL/LBL
200
Mechanism of action of bortezomib
what is a proteasome inhibitor
200
common associated mutations with BL?
What are t(8;14), t(2;8), t(8;22)
300
These are the core binding factor AMLs.
What are t(8;21) (q22;q22) or inv(16) (p13q22)/t(16;16) ?
300
Immunophenotype: CD20+ , CD10+ , BCL6+ , BCL2+ , and CD5−
Mutation: t(14;18)
is seen with this disease.
What is follicular lymphoma?
300
Treatment for Ph+ ALL
What is BCR-ABL TKI + either glucocorticoid or chemotherapy (typically also includes glucocorticoid)?
300
M spike > 2, free light chain ratio > 20 and clonal marrow plasma cells > 20% are indicative of THIS
What is the 2-20-20 rule for smoldering MM high-risk factors for progression?
300
Endemic Burkitt's lymphoma is associated with THIS viral infection
What is EBV?
400
The regimens below are used for THIS clinical scenario:
1) FLAG-IDA (fludarabine+ cytarabine+ idarubicin+ G-CSF) +/- venetoclax
2) CLIA (Cladribine+ idarubicin + cytarabine) +/- venetoclax
3) Vyxeos
What are the high intensity treatment options for relapsed/refractory AML?
400
Nodal/extranodal mass > 7cm, 3+ nodal sites of >3cm, high LDH, spleen > 16cm, organ compression, significant serous effusions, Hgb < 10, ANC<1.5, plt< 100 are part of THIS criteria and should warrant treatment
What factors are considered in GELF criteria?
400
Patient has hypersensitivity reaction, thromboembolism, pancreatitis, elevated liver enzymes, coagulopathy all as the result of this medication
What is peg-aspargase?
400
This CD3 xBCMA bispecific antibody is used to treat relapsed MM
What is teclistimab?
400
This regimen is given to reduce tumor bulk before starting intensive chemo
What is a "pre-phase" of glucocorticoid + vincristine + cyclophosphamide?
500
You order the labs below to check for THIS:
Count recovery (ANC> 1000) with plt > 100k and <5% blasts and no residual evidence of extramedullary disease (normal cytogenetics, negative molecular studies if applicable)
What is considered complete morphologic remission?
500
This is least toxic standard first line therapy for marginal zone lymphoma needing treatment.
What is rituximab monotherapy?
*H pylori EMZL without t(11;18) can be treated with H pylori eradication therapy alone
500
These drugs make up POMP maintenance.
What are 6-Mercaptopurine + Vincristine + Methotrexate + Prednisone?
500
Name the SLIM-CRAB criteria
What are (combined with at least >10% clonal marrow cells or at least one plasmacytoma): >60% clonal plasma cells in marrow, Serum free light chain (involved/uninvolved) ratio > 100, MRI with at least 1 focal lesion > 5mm,
Hypercalcemia (>11), Renal insufficiency (CrCl < 40 or Cr > 2), Anemia (Hgb < 10), Bony dz (1+ lytic lesion on imaging)
500
These regimens can be used for high-risk patients with Burkitt's lymphoma.
What are:
DA-EPOCH-R (for less fit patients), HyperCVAD,
or CODOX-M alternating with IVAC for 4 cycles?
(All patients get intrathecal methotrexate)