The Platelet Games
Is Ticagrelor a reversible or irreversible P2Y12 antagonist?
Reversible
What anticoagulant works by binding antithrombin and inhibiting clotting factors?
Heparin
What vitamin reverses the effects of warfarin?
Vitamin K
What is the most common oral iron formulation?
What is the MAIN adverse effect of Doxorubicin aka the "Red Devil"?
Cardiac toxicity
What is the MOA for the drugs Eptifibatide (Integrilin) and Tirofiban (Aggrastat)?
Glycoprotein IIb/IIIa inhibitors
What injectable anticoagulant class includes enoxaparin (Lovenox) and dalteparin (Fragmin)?
Low-molecular-weight heparin
What drug reverses unfractionated heparin using an acid-base interaction
Protamine
What category of drugs stimulate division and differentiation of erythroid progenitor cells in bone marrow?
Erythropoiesis-stimulating agents
Name the Method of Action for Rituximab
Binds to the CD20 antigen inducing cell lysis
What antiplatelet should be avoided in patients with previous history of TIA or CVA?
Hint: its P2Y12 antagonist
Prasugrel (Effient)
Activates plasmin
What drug can be administered to help reverse HIT?
Fondaparinux (Arixtra) or Argatroban
Name TWO adverse effects of Erythropoiesis-stimulating agents
Hypertension
Edema
Headache
Arthralgia
What must be given with Ifosfamide?
MESNA
Which antiplatelet agent binds to the PDE-3 inhibitor?
Cilostazol (Pletal)
What TWO direct oral anticoagulants inhibit factor Xa?
Apixaban (Eliquis)
Rivaroxaban (Xarelto)
Name the TWO drugs Andexxa reverses
Apixaban (Eliquis)
Rivaroxaban (Xarelto)
What two conditions does Luspatercept treat?
Thalassemia and Myelodysplastic syndrome
Name BOTH Tyrosine Kinase Inhibitors and their individual associated adverse effects
Dasatinib - Fluid Retention
Nilotinib - QT prolongation
What is the MOA and one adverse effect for Dipyridamole (Persantine)?
MOA: Inhibits metabolism of cAMP
AE: Headache, dizziness, SOB
What Thrombolytic Agent is contraindicated in CVA patients?
rPA (Reteplase)
This drug causes Dyspepsia, name the drug and its reversal agent for full points
Dabigatran (Pradaxa) and Idraucizumab (Praxbind)
Name three Black Box warning conditions of ESAs
Death, Stroke, MI, VTE, Thrombosis, Tumor progression or recurrence
Name all four drugs in the CHOP chemo regimen
C- Cyclophosphamide
H- Hydroxydaunorubicin (Doxorubicin)
O- Oncovin (Vincristine)
P- Prednisone