Lymphoma/Myeloma
What country is Burkitt lymphoma most commonly seen?
Africa
What lab value can help determine effectiveness of Coumadin?
INR
T/F: The patient can clot and bleed at the same time with DIC.
True
What causes ITP to be “set off”?
An infection, lupus, drug allergies
What are the causes of thrombotic thrombocytopenic purpura (TTP)?
Idiopathic, genetic
What virus is associated with Burkitt lymphoma?
EBV (Epstein Barr Virus)
What can determine the effectiveness of heparin?
PTT (partial thromboplastin time)
What can cause DIC?
Trauma, car accident, sepsis, cancer, endothelium injury
What is the bleeding risk for someone with ITP?
High bleeding risk d/t low platelets
What are diagnostics for thrombotic thrombocytopenic purpura (TTP)?
Blood tests (CBC), blood smears for broken/destroyed RBC
How do we diagnose Burkitt lymphoma?
Biopsy of lymph nodes or bone marrow
What does an increased PT mean?
Taking too long to clot
What food is high in vitamin K?
Green leafy vegetables
What is the treatment for ITP?
Palliative care, steroids, IVIG
What type of anemia is associated with thrombotic thrombocytopenic purpura (TTP)?
Hemolytic
What levels specific to multiple myeloma increase in the blood?
M-protein levels and Bence Jones proteins (blood and urine)
What is the lab value that can indicate a blood clot, but does not tell you where the blood clot is?
D-Dimer
When would you give a lot of Vitamin K?
In a Warfarin overdose
What drug complication involves the activation of thrombin that leads to thrombocytopenia?
Heparin Induced Thrombocytopenia (HIT)
Hemophilia is more common in who?
Males
What are clinical manifestations of multiple myeloma?
Hypercalcemia, anemia, increased blood viscosity, risk of fractures, renal failure, proteinuria
What are fibrin degradation products(FDP)?
The substances that are left over after the blood clot is destroyed
What is the goal for someone with DIC?
Keep them alive, control thrombosis, maintain organ function
What is the clinical s/s of Heparin Induced Thrombocytopenia (HIT)?
Increases thrombi – DVT, PE, CVA, thrombocytopenia
What are the treatments for hemophilia?
Clotting factor replacement