Cancers of the Skin
What does the following acronym stand for (ABDCE) in the setting of detection of melanoma
Asymmetry, Border Irregularity, Color variegation, Diameter > 6 mm, Evolving
pg. 600
This paraneoplastic syndrome seen in renal cell carcinoma results from ectopic hormone production and may cause hypercalcemia
What is parathyroid hormone-related peptide secretion
pg 702
This pattern of bleeding (such as petechiae, purpura, epistaxis, and menorrhagia), is most characteristic of platelet or vascular disorders rather than coagulation factor deficiencies
What is mucocutaneous bleeding (pg 961)
This classic triad describes the three major factors that predispose to venous thrombosis
What is Virchow’s triad (venous stasis, endothelial injury, and hypercoagulability) (pg 982-983)
Spoiled rich girl wears some expensive jewelry and later almost drowns
What is Titanic
A very rapidly growing low-grade form of squamous cell carcinoma that typically appears as a large dome-shaped papule with a central keratotic crater that usually spontaneously regresses
What is keratoacanthoma
pg 607
This classic triad of renal cell carcinoma is now uncommon and usually indicates advanced disease
What are hematuria, flank pain, and a palpable abdominal mass (pg 701)
This acquired platelet disorder is caused by autoantibody-mediated platelet destruction and often presents with isolated thrombocytopenia and normal coagulation studies
What is immune thrombocytopenia (ITP)
pg 965
This autoimmune condition is characterized by arterial and venous thrombosis, pregnancy morbidity, and antibodies against phospholipid binding proteins
What is antiphospholipid antibody syndrome (pg 988-990)
Billionaire nepo baby beats up petty criminals instead of working on his underlying trauma
What is The Batman
For a newly diagnosed cutaneous melanoma, what procedure is done to minimize the probability of local recurrence
What is wide excision of the lesion with a margin of normal skin
pg 603
This histologic subtype accounts for approximately 70-80% of renal cell carcinomas and arises from the proximal tubules
What is clear cell renal cell carcinoma (pg 700-701)
In this condition, abnormal shear stress leads to excessive cleavage of von Willebrand factor multimers, causing thrombocytopenia and microangiopathic hemolytic anemia
What is thrombotic thrombocytopenic purpura (TTP)
pg 969
This inherited thrombophilia results from resistance to activated protein C and is the most common genetic risk factor for venous thromboembolism
What is Factor V Leiden mutation (pg 985-986)
Grumpy landowner goes on a mission with his pet to rescue a princess from a fire breathing mystical creature
What is Shrek
Activating mutations in this receptor are found in a minority of cutaneous melanomas with chronic sun damage but are more common in mucosal and acral lentiginous subtypes
What is c-kit tyrosine kinase receptor
pg 605
Loss of this tumor suppressor gene on chromosome 3p leads to increased HIF activity and drives angiogenesis in clear cell RCC
What is the von Hippel-Lindau (VHL) gene (pg 701-702)
This inherited platelet disorder is caused by deficiency or dysfunction of the GPIb-IX-V complex, leading to impaired platelet adhesion to von Willebrand factor
What is Bernard-Soulier syndrome
pg 964
This anticoagulant therapy can paradoxically worsen thrombosis if started without appropriate overlap due to rapid depletion of protein C
What is warfarin (pg 986-987)
Depressed widowed father pairs up with forgetful stranger to find his disabled son
What is Finding Nemo
In melanoma, these two signaling pathways enhance tumorigenesis, chemoresistance, migration, and cell cycle dysregulation
What is MAP kinase and PI3K/AKT
Pg 602
Previously called renal medullary carcinoma, this is a type of RCC that is very aggressive and associated with sickle cell trait
SMARCB-1 deficient RCC
pg 687
What serotype of E. coli is most commonly associated with hemolytic uremic syndrome (have to be specific)
O157:H7
pg 925
What enzymes in the liver are required activation of clopidogrel
What is cytochrome p450
pg 939
This film documents the downfall of a startup after the founder botches product testing on endangered livestock
What is Jurassic Park