What's your sign, girl? I'm a Cancer.
The diagnosis is confirmed by bone marrow aspiration and biopsy showing >20% myeloblasts
This most common normocytic anemia is associated with low serum iron, low TIBC, and normal to high ferritin.
What is Anemia of Chronic Disease?
This common agent used in breast cancer treatment causes reversible non-dose related heart failure.
What is trastuzumab (Herceptin)?
Gold standard initial therapy for RA.
What is Methotrexate?
The most sensitive and specific test for SLE.
What is anti-DS DNA Ab?
A mutation in this gene is present in 97% of patients with Polycythemia Vera and about half of patients with essential thrombocytosis.
What is JAK2?
Immune related hemolysis is identified by this positive test.
What is Direct Coombs Test?
Hemorrhagic cystitis can be a consequence of this chemotherapeutic agent which is also used as an immunosuppressant in some rheumatologic conditions such as lupus nephritis.
What is Cyclophosphamide; Cytoxan?
It is important to evaluate for this spinal abnormality in patients with rheumatoid arthritis prior to surgery which could potentially lead to spinal cord compression during intubation.
Drug-induced lupus rarely has anti-dsDNA ab elevations but rather this antibody in addition to anti-Ro and anti-La antibodies.
What are anti-histone antibodies?
Lung tumor found in the apex of the lung possibly causing compression to the other local structures.
What is a Pancoast Tumor?
Deficiency of intrinsic factor produced by
gastric mucosa, which is necessary for absorption of vitamin B12 leads to this anemia.
What is pernicious anemia?
This chemotherapy agent used to treat Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, and ovarian cancer can lead to pulmonary fibrosis in which 1% of patients will die.
What is Bleomycin?
Polyarticular arthritis with dactylitis, nail pitting, characteristic rash, and "pencil-in-cup" deformity on plain films.
What is Psoriatic Arthritis?
Anti-U1RNP antibodies are highly specific and sensitive markers for this disease, a rare disease with overlapping features of SLE, scleroderma, and polymyositis
What is Mixed Connective Tissue Disease?
Eczematous appearing skin lesions involving the nipple and/or areola and associated with breast cancer.
What is Paget's Disease of the Breast?
Lethal form of alpha thalassemia characterized by deletion of all four alpha-globin genes (HBA1 and HBA2) in utero.
What is Hemoglobin Bart's hydrops fetalis (BHFS)?
Ototoxicity and nephrotoxicity are adverse effects of these platinum based compounds that are used as first-line therapy for various malignancies.
What are -platins; Cisplatin and Carboplatin?
Condition associated with sinus issues, epistaxis, hearing loss, lung infiltrates/nodules, hemoptysis, glomerulonephritis, palpable purpura and c-ANCA positive.
What is granulomatosis with polyangiitis (Wegener's)?
Limited Scleroderma AKA CREST syndrome will have this antibody positive as opposed to the anti-scl 70 ab seen in Diffuse Scleroderma.
What is anti-centromere Ab?
Cancer with chromosomal translocation 8;14 which involves the MYC gene on chromosome 8 and the immunoglobulin heavy chain locus on chromosome 14.
What is Burkitt's Lymphoma?
An infant born with normochromic, macrocytic anemia with triphalangeal thumbs and elevated erythrocyte adenosine deaminase activity likely has this anemia.
What is Diamond Blackfan Anemia?
Capecitabine or Xeloda is an oral prodrug of 5-FU which is used in the treatment of colon cancer and can cause this obscure cutaneous reaction that could impair criminal investigations.
What is loss of fingerprints?
Characterized by painful, deep ulcers with undermined edges and peripheral redness, it is associated with Ulcerative Colitis.
What is Pyoderma Gangrenosum?
A condition often suspected in recurrent 1st trimester loss of pregnancy due to blood clots will have these 3 antibodies.
What are antiphospholipid antibody, anticardiolipin antibody, anti-beta-2 glycoprotein 1 antibodies?