Site of Primary Infection
These herpes viruses primarily infect the mucosa
What are HSV-1, HSV-2, and VZV?
This herpes virus is latent in the trigeminal ganglia
What is HSV-1?
This anti-herpes viral agent is converted to a monophosphate form by thymidine kinase then a triphosphate form
What is acyclovir?
This anti-influenza agent inhibits viral uncoating of influenzae A by inhibiting the integral membrane ion channel M2
What is Amantadine?
This retrovirus is an enveloped icosahedron diploid single stranded RNA virus
What is HIV?
This herpes virus primarily infects the dermis
What is HHV-8?
This herpes virus is latent in B cells
What is EBV?
This deoxyguanosine analog is phosphorylated to the tri-phosphate form by a viral phosphotransferase and inhibits viral DNA polymerase
What is ganciclovir?
This anti-influenza agent inhibits viral release by inhibiting the viral enzyme neuraminidase
What is oseltamivir?
This anti-retroviral agent (and class) inhibits the integration of viral DNA into host cell DNA
What is raltegravir (INSTI)?
This herpes virus primarily affects mononuclear cells
What is HHV-6?
This herpes virus is dormant in the sacral ganglia
What is HSV-2?
This anti-herpes viral agent has a similar MOA as acyclovir but does not cause chain termination
What is famciclovir?
This antiretroviral agent prevents the interaction between CCR5 and gp120 inhibiting binding of HIV to the host cell
What is maraviroc?
This anti-retroviral agent inhibits virus attachment and penetration by binding gp41
What is enfuvirtide?
This herpes virus primarily infects the mucosal epithelial cells and B cells
What is EBV?
This herpes virus is latent in the dorsal root ganglia
What is VZV?
This anti-herpes viral agent inhibits viral DNA synthesis leading to chain termination and inhibition of viral DNA polymerases
What is cidofovir?
This antiretroviral agent (and class) must be phosphorylated in order to be active and bind reverse transcriptase preventing the formation of DNA from virus
What is abacavir (NRTI)?
This antiretroviral agent (and class) inhibits viral maturation
What is atazanavir (PI)?
This herpes virus primarily affects mononuclear cells and epithelial cells
What is CMV?
These herpes viruses are latent in mononuclear cells
What are CMV and HHV-6?
This anti-herpes viral agent inhibits pyrophosphate cleavage
What is foscarnet?
This antiretroviral agent (and class) directly binds to reverse transcriptase and inhibits it
What is doravirine (NNRTIs)?
This opportunistic infection is commonly seen in people with CD4 counts <200/mm3
What is PCP pneumonia?