Antiretroviral therapy is recommended in all HIV infected individuals. Exception maybe be made if
What is patient is not willing or able to commit to treatment
100
Name the 6 classes of antiretrovirals
What are NRTI, NNRTI, PI, ISTI, Entry inhibiors, Pharmacokinetic enhancers
100
Atazanavir/ritonavir + tenofovir/emtricitabine was removed from the guidelines as a preferred regimen because
What is greater rate of toxicities (increased discontinuation in clinical trials)
100
Atazanavir
What is Reyataz
100
Lopinavir/ritonavir
What is Kaletra
200
Name two benefits of maintaining undetectable viral loads
What is improved immune function, improved quality of life, lowers risk of AIDS defining and non AIDS defining conditions, prolonged life
200
Initial therapy for a treatment naive patient should include 2 agents from which class?
What is NRTI
200
What is the reason efavirenz/tenofovir/emtricitabine was removed from the preferred guideline list?
What is high rate of CNS toxicity specifically suicidality?
200
Darunavir
What is Prezista
200
Abacavir
What is Ziagen
300
Name 2 non AIDS defining complications that can be prevented by suppressing viral load
What is HIV associated nephropathy, Co-infection with Hep B and C, Cardiovascular disease, malignancies, neurological complications
300
In addition to 2 NRTI what are the 3 classes that can be used in combination for initial therapy
What is ISTI, PI, NNRTI
300
What is the only PI based regimen currently recommended as preferred in the guidelines
What is darunavir/ritnoavir + tenofovir/emtricitabine
300
Ritonavir
What is Norvir
300
Dolutegravir
What is Tivicay
400
Name two concerns regarding early initiation of therapy
What is Drug toxicities impact on quality of life, non-adherence, early development of resistance, cost
400
Selection of initial therapy should take into consideration the following: (name 3)
What is efficacy, toxicity, pill burden, dosing frequency, drug interactions, resistance testing, comorbid conditions, cost
400
Cobicistat is available coformulated with which PIs (2)
What is Atazanavir and Darunavir
400
Tenofovir
What is Viread
400
Efavirenz
What is Sustiva
500
Name 3 conditions favoring urgent initiation of therapy
What is Pregnancy, AIDS defining conditions, Acute OI, HIVAN, Low CD4 count, Acute/early infection, Hep B/C coinfection, Rapidly declining CD4 counts, High viral load
500
Name the two pharmacokinetic enhancers
What ritonavir and cobicistat
500
List 2 advantages of choosing an INSTI regimen as initial therapy?
What is high efficacy, excellent safety/tolerability, low number of drug-drug interactions