Abbreviations
TDF/TAF
Tenofovir (disoproxil fumarate and alafenamide)
Dolutegravir
Integrase inhibitor (INSTI)
What drug class competitively inhibits the reverse transcriptase enzyme
NRTIs (gotta love the nukes)
Assesses overall immune status (a key cell in our immune system)
CD4 T-lymphocyte count (cells/mm3)
Which first line treatment options contain only two drugs?
Dovato (Dolutegravir/Lamivudine)
BIC
Bictegravir
Darunavir
Protease Inhibitor
CYP3A4 inhibitor that is used as a "booster" in regimens
Cobicistat
Assesses effectiveness of HIV therapy; useful for disease progression, indirect adherence monitoring, and potential for treatment failure/resistance
HIV RNA - viral load (copies/mL)
Which first line treatment HIV drug needs HLA-B 5701 allele testing before use?
Triumeq (Dolutegravir/Abacavir/Lamivudine)
/r
Ritonavir
Triumeq
Two NRTIs and an INSTI
This drug class inhibits the budding and maturation of the HIV virus. (hint: it inhibits an enzyme)
Protease Inhibitors
This lab may be falsely low in patients living with HIV
A1c
At what CrCl would you not want to start Biktarvy?
CrCl <30 mL/min
FTC
Emtricitabine
Ritonavir (technically a part of two classes but which one do we mainly use it for)
Pharmacokinetic Booster
This drug class prevents HIV DNA from inserting into the host cell DNA
Integrase Inhibitors
We test for this gene to determine if a patient can receive abacavir due to the risk of severe allergic reactions
HLA-B*5701
Name one side effect that can be seen with Biktegravir.
Weight gain (integrase inhibitors)
DRV
Darunavir
Symtuza (hint there are three drugs with a booster)
This medication non-competitively inhibits the reverse transcriptase enzyme and must be taken with food.
Rilpivirine
Vitamin level that is commonly deficient in patients living with HIV
Vitamin D (<20 ng/mL indicates deficiency)
Why would Genvoya be a poor option to use in a patient with seizures?
Contains Cobicistat (CYP3A4 inhibitor)