Name Game: Brand vs. Generic
The single tablet regimen regimen Biktarvy contains these three active ingredients
What are bictegravir, tenofovir alafenamide, and emtricitabine?
This antiretroviral agent is contraindicated in the presence of this major histocompatibility complex class I allele due to the risk of hypersensitivity reaction
What is abacavir?
This resource is a website where you can enter resistance mutations to obtain a cumulative genotype and interpret drug resistance
What is Stanford University HIV drug resistance database?
This free online resource checks for drug interactions with HIV antiretroviral agents
What is Liverpool HIV drug interaction checker?
In appropriate patients, this is the only 2-drug regimen recommend as initial treatment in ART-naive patients
What is Dovato (dolutegravir/lamivudine)?
The long-acting injectable Cabenuva contains this INSTI and NNRTI
What is cabotegravir and rilpivirine?
The entry inhibitor Maraviroc requires this assay prior to starting treatment
What is a Trofile (co-receptor tropism assay)?
This mutation confers high level resistance to emtricitabine and lamivudine but increased susceptibility to tenofovir
What is M184V/I?
This class of antiretroviral agents is known for the drug interaction of cationic chelation
What are integrase strand transfer inhibitors?
Per the guidelines, the definition of virologic failure is the inability to achieve or maintain suppression of viral replication to HIV RNA level _____
What is <200 copies/mL?
The single tablet regimen Descovy contains these two NRTIs
This protease inhibitor has antiretroviral activity but is used solely as a pharmacokinetic booster
What is ritonavir?
These are the HIV RNA lower limits of detection for RT/PR and INSTI resistance testing at AHWFB respectively
What are 500 copies/mL and 1000 copies/mL?
This class of antiretroviral agents are contraindicated with lovastatin and simvastatin
What are protease inhibitors?
In HBV/HIV co-infection, this antiretroviral agent should be included in the backbone of a fully suppressive ARV regimen
What is TAF or TDF?
This triple threat contains the ingredients dolutegravir, abacavir and lamivudine
What is Triumeq?
ARV regimens containing this NNRTI should be taken on an empty stomach to minimize the risk of nervous system symptoms such as insomnia, dizziness and abnormal dreams
What is efavirenz?
This NNRTI mutation confers high-level resistance to nevirapine and efavirenz but does not affect rilpivirine and doravirine
What is K103N?
These two antiretroviral agents have decreased absorption with acid suppression therapy
What are rilpivirine and atazanavir?
Per guideline recommendations, what three reasons would you not consider Dovato in treatment-naive patients?
What are HIV RNA >500,000 copies/mL, known HBV co-infection (or unknown status), no genotypic resistance testing for RT?
The single tablet regimen Stribild contains these four ingredients, including a PK booster and an NRTI that has more risks for renal and bone toxicity
What are elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate?
ART regimens containing any of these four antiretroviral agents need to be taken with food (400 calorie meal)
What are atazanavir, rilpivirine, elvitegravir, darunavir?
This mutation reduces susceptibility to a majority of NRTIs including tenofovir
What is K65R?
A patient is started on Symtuza, which may interact with which of the following medications: PO vitamin D, Advair diskus, PO lisinopril
What is Advair (fluticasone/salmeterol)?
Per the guidelines, what two antiretroviral agents are known to have a high barrier to resistance?
What are dolutegravir and boosted darunavir?