what systemic therapy can be used for prevention of H/N cancer?
What is
nothing
100
A patient with T2N0M0 head and neck cancer is what stage?
What is
Stage II
100
What virus is most commonly linked to OP cancer?
What is
HPV.
100
By definition a complex karyotype has more than _______ abnormalities?
What is
3
100
Which FLT3 abnormality is a poor prognosis
What is
ITD
200
Name two risk factors for SCCHN outside of Etoh and Tobacco.
What is
1)viruses- HPV/EBV
2)fanconis
3)aromatic hydrocarbons
200
Patients with stage IV head and neck cancer have distant metastases? True/false
What is
false
200
Which virus is associated with nasopharyngeal cancer?
What is
EBV
200
Name the two CBF Translocations in AML.
What is
t (8;21)
inversion 16
200
Prior to treatment with Arsenic, you should check what test?
What is
EKG (QT pro__________)
300
Neoadjuvant chemotherapy followed by chemoradiation therapy improves survival compared to chemoradiation therapy alone for H/N cancers...true/false
What is
False
300
A patient with T1N2M0 squamous cell carcinoma of the larynx has what stage disease?
What is
stage III
300
Which HPV serotypes are associated with oropharyngeal cancer?
What is
HPV-16 and HPV-18
300
In SCCHN, the earliest genetic changes are?
What is
loss 9p and 3p then 17p (last 11q, 13q, 14q)
300
The least sensitive test to follow for MRD in AML?
What is
Marrow
400
Adding Cetuximab to Radiation to treat unresectable OP/HP/laryngeal cancer increases OS?
What is
True.
400
The presence of bilateral nodal involvement in head and neck cancer is what "N" stage?
What is
N2c
400
What HPV oncogenes are necessary for malignant transformation?
What is
E6 and E7
400
The abnormality found in secondary AML due to topoisomerase II inhibitors is?
What is
11q23
400
Good risk CN AML might have which molecular abnormality?
What is
CEPBA or NPM1 (without FLT3 HD)
500
concomitant CP and radiation therapy for laryngeal cancer improves survival compared to induction chemotherapy and radiation therapy..... true or false
What is
false
500
At what size does a lymph node have to be for the patient to be classified N3? N3 classification means what overall stage?
What is
6 cm
IVb
500
Name the two viral oncogens associated with EBV infection.
What is
LMP-1
EBNA-1
500
In Cytogenetically-normal AML, name the three abnormalities known to be prognostically important are?
What is
NPM1
CEPBA
FLT3
500
Which FAB classification of AML is found most in pediatric patients with Downs syndrome with what associated mutation?