Fundamentals of immunity
the seven parts that make up the innate immune system, cells and systems.
What are dendritic cells, macrophages, neutrophils, basophils, eosinophils, mast cells, and complement?
the pathogen that occupies the niche of phagolysosomes
What is Leishmania
VSG
What is Variant Surface Glycoprotein that allows for antigenic variation in T. brucei
the relationship between parasitic helminth infections and autoimflamatory diseases
What do helminth infections cause with their immunomodulating stuff
T3SS
What is a Swiss Army knife for bacteria that uses a syringe-like structure to send effector proteins straight from the bacterial envelope to the cellular membrane?
The five parts that make up the adaptive immune system (In this lecture)
What are B cells, CD4 T cells, Plasma B cells, CD8 T cells, and Antibodies
A parasite that occupies the niche of liver then erythrocytes (RBC)
What is plasmodium
The three principles of antigenic variation
1. ANY GIVEN CELL WILL EXPRESS ONE ANTIGEN AT A TIME 2. THEY HAVE TO BE ABLE TO SWITCH AND ALLOW PART OF THE POPULATION TO SURVIVE (and most to die) 3. THE PATHOGEN CONTAINS A LARGE FAMILY OF VARIABLE HOST GENES TO ALLOW SWITCHING
the intra cellular transciption factor and what it does
what is foxp3 and how does it control regulatory t-cells? (10x t cells for every transcription factor to 6x t cells for every transcription factor)
It was evolved from the flagellum
How do these T3SS look like the flagellum but have a hook and no locomotion functions?
The proccess in which the adaptive immune system works
What is transport of antigen to lymphoid organs—Recognition by naïve B and T cells—Production of effector cells—Removal of infectious agent
The two ways that Leishmania avoids getting killed
what are the inhibition of phagosome-lysosome fusion and the inhibition of antigen presentation machinery?
Richard Watson
Who's that one guy who came up with the principle of contingency genes when he noticed that the rate and pattern in which a genome mutates is not uniform?
Chaperone proteins with T3SS
How do the proteins get excreted in an unfolded state and enter the cell and give it to the sorting platform?
The functions of activated B cells
What is an ANTIBODY (surface Immunoglobulin) that is different on each B cell with unique specificity?
The way that Plasmodium avoids getting killed
what is evasion of splenic clearance through cytoadherence, generalised immunosuppression via effects on immune cells?
The use of pseudo genes
what does T. brucei use to feed into an expression site and recombine so they can have more vsg diversity
The three main ways we have studied the structure of T3SS
What is x-ray crystalography, homologous structures, and cry-EM/cryo TP
The functions of an activated T cell
each T cell has unique specificity but they're the ones who bind to the antigen it's self
LPG's role in Leishmania
What is the inhibition of the p67phox, so that the phagocytosis will not progress or mature into a phagolysosome
Antigenic variation purpose
What is to sustain prolonged infection or to avoid herd immunity
The 6 main effectors that salmonella uses and what they do.
what are SipA, and SipC that are actin binding proteins,
what are SobB and SobE and SobE2 that bind and stimulate the Rhogtpase
and what is SptP that works as an antagonist and switches off the SopE's stuff bc it has a longer half life?