What Was That Drug Again?
What 2 drugs are found in Suboxone?
Buprenorphine
Naltrexone (not activated if taken orally)
What drug is used to treat Irritability associated with Autism and improve global symptoms of PTSD??
Risperdal
What dopamine agonist is often used to help treat neuroleptic malignant syndrome?
Bromocriptine
What kind of headaches are Opiates least effective for managing pain & probably should be avoided due to risk of abuse potential?
Tension Headaches
What is mechanism of action for Fomepizole, which is used to help treat methanol overdose?
Inhibit Alcohol Dehydrogenase
What class of drugs is used to treat premenstrual dysphoric disorder?
Contraceptives
What Mu Opiate Agonist is used to treat diarrhea?
Loperamide
What drug carries the side effect profile of
Tremor, Nephrogenic Diabetes Insipidus (ADH Antagonism), Hypothyroidism, Ebstein's Anomoly and Kidney Dysfunction
Lithium
Use of Suvorexant (Belsomra) is contraindicated in patients with what condition?
Narcolepsy
What is the mechanism of action for Benzodiazepines?
Allosteric Modulators of GABA A Receptor,
Increases frequency of opening of inhibitory chloride channels
Lorazepam
Midazolam (Versed)
What drug can be given to reverse Benzodiazepine OD?
Flumazenil
What is the predominant side effect that prevents patients from staying compliant on SSRIs?
Sexual Dysfunction
What Anxiolytic is contraindicated in patients on MAO inhibitors such as Buproprion?
Buspirone (Buspar)
What is mechanism of action for Cyproheptadine, the drug of choice for treatment of Serotonin Syndrome?
Potent antagonist of the 5-HT2 receptors,
also has antihistemic effects by functioning as antagonist of H1 Receptors
What TCA is commonly used for treatment of Chronic Pain & Migraine Prevention?
(It also has shown some efficacy for treatment of OCD and Insomnia).
Amitryptiline
What is the drug of choice for management of Bipolar Disorder, particularly for antidepressant effects?
Lamotrigine
What is the unique side effect associated with ambien over other sleep medications?
Sleep Eating/Walking
What class of drugs must one be cautious of taking when eating, Aged Cheese, Tap/Unpasteurized Beer, Certain Wines and Soy Products?
MAO Inhibitors (Buproprion, Phenelzine)
What is the mechanism of action of Atomoxetine (Strattera)
Norepinephrine Reuptake Inhibitor
What anxiolytic is only really approved for treatment of Performance Anxiety and Akathisia from Antipsychotics?
Propranalol
What drug an be used to help moderate prolonged withdrawal symptoms from alcohol by interfering with glutamate transmission?
Acamprosate
What is the major side effect of Trazodone and Nefazodone?
Priapism (Prolongued Erection over 4 hours)
Propranolol is contraindicated in patients who have what chronic disease?
Asthma
What mechanism of action is responsible for the addictive properties of Nicotine?
Binds and activates central nicotinic ACH receptors resulting in release of Dopamine and other neurotransmitters
What is the drug of choice for treatment of Binge Eating Disorder (Not Bulimia or Anorexia)?
Lisdexamfetamine (Vyvanse)
What two benzos are preferred for treatment of insomnia?
Triazolam
Temazepam
What SSRI is most teratogenic?
Paroxetine (Paxil)
What class of drugs carries biggest risk of causing serotonin syndrome when administered with Peridine?
MAOIs (like Phenelzine)
What is mechanism of action for Zolipidem?
GABA-A Allosteric Regulator, specifically targets Alpha 1 subunit
What drug serves as a Melatonin Receptor Agonist acting in the suprachiasmatic nucleus to try and help regulate sleep cycles?
Ramelteon
What is gold standard for treatment of OCD?
Clomipramine
What is the main side effect associated with Suvorexant?
Vivid Dreams or Nightmares
What SSRI cannot be given to a patient on Ramelteon?
Fluvoxamine
What is the mechanism of action for second generation / atypical antipsychotics?
5HT2A Receptor Antagonist
D2 Receptor Antagonist
What 3 Benzos are safe to use in patients with Liver Disease?
Oxazepam
Temazepam
Lorazepam
(metabolized Out of The Liver)
What antidepressant is used to treat diabetic peripheral neuropathy/pain disorders?
(It is also commonly used to help with pain control in Fibromyalgia)
Duloxetine (cymbalta)
What two antipsychotics carry risk of causing metabolic syndrome?
Olanzapine
Quentiapine
What class of drugs have been shown top induce mania when given to Bipolar Patients for treatment of Depression?
SSRIs (presumably SNRIs as well)
What is mechanism of action for Suvorexant (Belsomra)?
Orexin Receptor Antagonist
This drug is a mu opiate antagonist that is linked to polyethylene glycol.
The polyethylene glycol prevents the drug from entering CNS so it's only real function is to blocks opiate effect on enteric nervous system. It is used predominantly to reverse opiate induced constipation.
Naloxegel (Movantik)
What stimulant is only approved for the treatment of Narcolepsy?
What sleep medication has the least side effect profile?
Ramelteon
What drug should be avoided in patients on Digoxin because it decreases clearance and may result in Digoxin Toxicity?
Quinidine (Malaria Drug)
What is the mechanism of action for Buprenorphine?
Partial Mu Opiate Agonist
Delta & Kappa Opiate Antagonist
What mood stabilizer is most strongly associated with the risk of causing Steven Johnson Syndrome?
Lamotrigine
Olanzapine
What second generation antipsychotic is most likely to cause akathisia?
Ariprazole
What mood stabilizer cannot be used concurrently with Lamotrigine?
Valproic Acid
What is the mechanism of action for TCAs?
Inhibit SERT and NET
Inhibit H1 Histaminic Receptors
Inhibit M1 Muscarinic Cholinergic Receptors
Inhibit Alpha 1 adrenergic receptors
Inhibit Voltage Gated Na Channels