Name the compensatory response to a sudden decrease in BP (hint, think vasodilators)
reflex tachycardia
Secondary HTN accounts for ___% of all HTN cases
10%
What is another name for Aldosterone antagonists
Potassium sparing diuretics
Antihypertensive medication must be DCed gradually to prevent...
rebound HTN
Name 2 antihypertensives that are contraindicated in pregnancy
Lisinopril, Losartan. Also accept- Aliskiren
Name the two treatment options for hypotension (general)
IVFL, Vasopressors
First line for chronic HTN, this drug class bocks Ca ion channels in the heart, blood vessels or both
Ca Channel Blockers
Verapamil is a ___ CCB whereas Nifedipine is a ___ CCB
nonselective (affects arterioles & heart), selective (affects arterioles)
Melatonin may increase BP and HR if taken with this Ca channel blocker
Nifedipine
Name the SBP and DBP range for stage 2 HTN
> 140, >90
Hypertensive Emergency is defined as a SBP > ___ and a DBP > ___
180, 120
Name the drug: this ARB may produce dizziness & fainting (encourage slow position change), hypoglycemia, angioedema and should not be taken with Grapefruit juice
Losartan
Name the SBP and DBP for stage 1 HTN
130- 139, 80- 89
Name the medication: this drug improves survival if given within 24 hours of MI, should never be taken during pregnancy, can increase serum potassium levels and NSAIDs can decrease its efficacy
Lisinopril
Name the drug: This Ca channel blocker may cause a paradoxical increase in anginal pain and should be discontinued slowly to avoid rebound hypertension
Nifedipine (Procardia XL)
In the treatment of HTN, this drugs class primarily reduces blood volume through urinary excretion of H2O & electrolytes
Diuretics
Name the drug: this direct-acting vasodilator can cause reflex tachycardia and should be started at a low dose and GRADUALLY increased until therapeutic response met
Hydralazine
This enzyme is secreted by the kidneys and is later converted to angiotensin 1 and angiotensin 2 (via ACE)
Renin
This drug is one of a kind, directly lowers plasma renin levels and should NOT be used in combo w/ ACEIs or ARBs in pts w/ serious CKD
Aliskiren
This drug class acts on the RAAS by blocking the effects of angiotensin 2; often used in combination w/ thiazide diuretics, it is notorious for angioedema
ACEIs (Lisinopril)
Dugs that affect RAAS do two primary things in the body
decrease BP and increase urine volume
Name the drug class: acts on the RAAS, blocks the effects of angiotensin 2 AFTER it is formed, and affects both peripheral resistance and blood volume
Angiotensin Receptor Blockers (ARBs)
Doxazosin (Cardura)
Name the 3 factors that contribute most to HTN
CO, PR, blood volume
This hormone's primary action is to increase Na reabsorption in the kidney, this reabsorption ultimately causes the body to retain water increasing blood volume & BP
Aldosterone