Genetics
This chromosome carries the gene responsible for Huntington's disease.
What is chromosome 4
This is the hallmark movement symptom of Huntington's, which is involuntary and jerky.
What is chorea?
The disease is named after this American physician who first described it in 1872.
Who is George Huntington?
Currently, there is no cure for Huntington’s disease, but this type of medication can help manage symptoms like chorea.
What are antipsychotic or neuroleptic drugs?
This important research finding in 1993 helped pinpoint the exact location of the gene causing Huntington’s.
What is the identification of the HTT gene on chromosome 4?
A person with this number or more repeats of the CAG trinucleotide in their DNA is at high risk of developing Huntington's.
What is 36 repeats?
This type of cognitive decline is commonly observed in individuals with Huntington’s disease.
What is executive function impairment?
This year, the first genetic test for Huntington’s disease was developed.
What is 1993?
This type of therapy focuses on improving the quality of life through physical, speech, and occupational therapies.
What is symptomatic therapy or supportive therapy?
This major research breakthrough in the 2000s suggested that silencing the HTT gene might help alleviate symptoms of Huntington’s.
What is gene silencing?
If one parent has Huntington's, each child has a ____ chance of inheriting the disease.
What is 50%?
These are the mood-related symptoms that often appear in people with Huntington’s disease.
What are depression and irritability?
This famous scientist was one of the first to identify the gene that causes Huntington’s disease.
Who is James Gusella?
This non-pharmacological approach involves the use of devices or strategies to aid with motor function, especially in later stages.
What are assistive devices or mobility aids?
This method uses stem cells to try to create new healthy neurons that could replace damaged ones in Huntington’s patients.
What is stem cell therapy?
This type of mutation in the HTT gene leads to Huntington's disease.
What is a "CAG repeat expansion"?
A person with Huntington’s disease may experience difficulty with this task, which involves both coordination and thinking.
What is speech or swallowing?
In the early 20th century, this country experienced a population where Huntington’s was unusually prevalent, particularly in the Lake Maracaibo region.
What is Venezuela?
This experimental class of drugs aims to reduce the production of the mutant Huntington protein.
What are gene silencing or RNA-based therapies?
This country was the first to approve a genetic test for Huntington’s disease in 1993.
What is the United States?
A test that can confirm whether someone has the gene for Huntington’s before symptoms appear.
What is genetic testing or a predictive test?
This phenomenon occurs when people with Huntington’s disease start to show psychiatric symptoms before motor symptoms.
What is "pre-manifest" or "early-onset" Huntington's disease?
The term "Huntington's ______" comes from this Greek word meaning "dance" or "to move rhythmically."
What is "chorea"?
This is a potential treatment that is still in clinical trials, aiming to directly target the mutant gene responsible for Huntington’s.
What is CRISPR gene editing or antisense oligonucleotides?
This long-term study is focused on understanding the early stages of Huntington's and testing potential treatments.
What is the TRACK-HD study?