All About That Staph!
Vancomycin has no activity against this group of organisms
What is Gram-negative bacteria?
This report is hospital-specific and summarizes local antimicrobial susceptibility patterns to guide empiric therapy
What is an Antibiogram?
This scoring system helps determine inpatient vs outpatient management of CAP
What is CURB-65?
This antibiotic is recommended as first-line for uncomplicated cystitis due to efficacy and low resistance rates
What is Nitrofurantoin?
This antibiotic uses a ‘Trojan horse’ mechanism by binding iron to gain entry into gram-negative bacteria
What is Cefedirocol?
This pharmacokinetic parameter is now preferred over trough levels to guide vancomycin dosing
What is AUC/MIC?
This stewardship strategy involves narrowing antibiotic therapy based on culture and susceptibility results
What is De-escalation?
This is the typical recommended duration of therapy for hospital-acquired and ventilator-associated pneumonia
What is 7 days?
This antibiotic class is considered the drug of choice for infections caused by ESBL-producing organisms
What are Carbapenems?
This combination of a beta-lactamase inhibitor and a penicillinase-resistant beta-lactam is FDA-approved for treating infections caused by carbapenem-resistant Acinetobacter Baumannii (CRAB)
What is Sulbactam-Durlobactam?
This beta-lactam has activity against MRSA
What is Ceftaroline?
This antibiotic combination raises a stewardship concern for a patient receiving both piperacillin-tazobactam and metronidazole
What is Duplication of therapy / Unnecessary Anaerobic coverage?
Empiric therapy for hospital-acquired and ventilator-associated pneumonia should include coverage for these two organisms
What are MRSA and Pseudomonas aeruginosa?
This antibiotic can cause orange discoloration of urine and body fluids
What is Rifampin?
This antibiotic was traditionally only available as an single-dose oral agent for uncomplicated UTIs but now has an IV formulation for multidrug-resistant infections
What is Fosfomycin?
This is an appropriate alternative for MRSA infections when vancomycin cannot be used
What is Linezolid or Daptomycin?
Treatment for symptomatic bacteriuria
What is No treatment (unless pregnant or undergoing urologic procedure)?
Recommended empiric inpatient CAP regimen includes combination therapy of these 2 drug classes
What is a Beta-lactam + Macrolide?
This antibiotic is associated with tendon rupture and QT prolongation
What are Fluoroquinolones?
This newly approved oral antibiotic is the first in its class and has shown activity against resistant uropathogens, with trials demonstrating superiority to nitrofurantoin
What is Blujepa (gepotidacin)?
These 3 oral antibiotics are commonly used for community-acquired MRSA infections
What are TMP-SMX (Bactrim), Clindamycin, and Doxycycline?
This is the stewardship intervention for a patient is on vancomycin and piperacillin-tazobactam with blood cultures that just came back with MSSA
What is De-escalation to an anti-staphylococcal beta-lactam?
In CAP, macrolides are added to cover these organisms that are not susceptible to beta-lactams
What are atypical pathogens (Mycoplasma, Chlamydia, Legionella)?
This antibiotic class is associated with ototoxicity, especially with prolonged use
What are Aminoglycosides?
This lipoglycopeptide antibiotic has an unusually long half-life of approximately 14 days, allowing for once-weekly or single-dose therapy for skin infections
What Is Dalbavancin?