Med Chem
This is the amount of times acyclovir must be phosphorylated to become the active molecule?
What is 3?
These classes of medication have extensive CYP3A4 interactions.
What are NNRTIs and PIs?
These fungi are resistant to fluconazole, wb AmpB, echinocandins>
what is:
C.krusei, A.terrous, A.fumagitis/A.flavis
AmpB: C.lusitania
echinocandins: all dimorphic
ppx: 75 mg QD x5 days
tx: 75mg BID x5 days
*peramivir cannot be used*
This is the first line tx for giardia.
What is tinidazole or nitazoxanide?
This moiety is where the 14a demethylase works on the triazole antifungals? (explain what happens)
What is the basic Nitrogen in the triazole ring?
This is the generic of Truvada (also do Descovy)
What is:
Truvada: emtricitabine TDF
Descovy: emtricitabine TAF
What is CrCl<50
This symptom is rarely seen in cold, but common in the flu.
What is a fever, myalgia, chills, weakness?
This is the major symptom associated with giardia, cryptosporidium, and amebiasis
what is diarrhea
These molecules appear to have Phe and Pro in them in order to look like the ____ enzyme. Give one example of a drug in the class.
What are protease inhibitors.
What is:
TDF: CrCl<50
TAF: CrCl<15
why: TAF metabolism inside the cell so less nephrotoxic and less SE
This medication is contraindicated in HF.
What is itraconazole?
This type of patient will recieve steroids for COVID. also which steroid.
dexamethasone-only if in need of O2
These medications (class or drugs) are added for both chemo ppx and treatment when is is P.vivax or P. ovale.
What are: 8-aminoquinolines: primaquine or tafenoquine?
side effects?
This is why the SAR of this class appears to look like nucleotides? (basically what is the MOA)
What are the NRTIs?
This medication MUST have HLAB1507 testing done before hand.
What is abacavir?
why:
This is the first line treatment of Blastomyces.
What is itraconazole for mild-mod and LAmB for mod-severe?
all 6-12 mos (CNS=12mos)
This covid medication needed a renal dose adjustment, has many DDI, and must be started within 5 days of sx.
Paxlovid (CrCl<60)
This drug is first line for hookworms, intestinal roundworms, and tapeworms.
What is albendazole?
This drug is the most potent CYP3A4 inhibitor.
What is ritonavir?
These are the first line ART options.
What is:
bictegravir/TAF/emtricitabine (one drug)
dolutegravir/abacavir/lamivudine (one drug)
dolutegravir + Truvada or Descovy
This is the first line treatment for Aspergillosis.
What is voriconazole?
also: ADE?, duration?, s/sx of aspergillosis?
These patient factors put a patient at risk for severe COVID and should receive antiviral therapy
over 50 (esp >65), >6mos since last vaccine, unvaxed, immunocompromised, DM, chronic respiratory disease, obese
This helminth needs counseling to clean clothing and bedding daily in hot water.
What are pinworms?
what is the tx?