Part 1
What are two surface barriers of the innate defense?
Mucous membranes and skin
The adaptive immune defense uses what two overriding cells?
T cells and B cells
T cells during maturation divide in to what two kinds of T cells?
CD4 or CD8
Name two autoimmune diseases
Rheumatoid Arthritis, Myasthenia Gravis, Graves Disease, Type 1 Diabetes, Systemic Lupus Erythematosus or Glomerulonephritis
Who is getting coronated tomorrow?
Charles III
Name two internal defenses of the innate defense system
Phagocytes, NKC, Inflammation, Antimicrobial proteins,Fever
Antibodys are produced by what cell type?
Plasma cells made from B lymphocytes
When a CD4 cell gets activated it can proliferate and differentiate in to three different kinds of cells these are what?
Memory, Helper T and Regulatory
What happens in an autoimmune disease?
System loses its ability to distinguish self antigens from foreign antigens so the body produces antibodies and cytotoxic T cells that destroy its own healthy cells tissues.
Name one inflammatory chemical?
Histamine, Prostaglandins, Kinins
Name one structural modification of the innate system?
Cilia
How do antibodies stop foreign antigens from infecting other cells?
Agglutination, Neutralization, Precipitation
True or False? Class 2 MHC proteins are found on all nucleated cells
False only APC's
Acquired immune deficiency syndrome (AIDs), which interferes with the activity of what immune system cell type?
Helper T cells
What do interferons do?
interfere with the ability of viruses to replicate and cause disease in a cell.
What chemical release causes a fever?
Pyrogens
During maturation what does a lymphocyte learn?
Immunocompetence and Self tolerance
Class 1 MHC proteins carrying an antigen are recognized by what kind of T cell?
CD8
Which group of immune system problems is a congenital or acquired condition that impairs the production or function of immune cells or certain molecules such as complement or antibodies?
Immunodeficiencies
What is chemotaxis?
Neutrophils follow chemical trail to site of injury
During the steps of phagocytosis what fuses with a phagocytic vesicle?
Phagolysosome
What are two ways active humoral immunity can be gained?
Vaccine or Natural Infection
If a CD8 cell comes across a APC displaying foreign antigens how would a cytotoxic cell respond?
Leave the cell alone but go around hunting for the antigen it displayed to kill it.
What are the three main groups of problems associated with the immune system?
Immunodeficiencies, autoimmune diseases and hypersensitivities
How many head coaches has Leeds United soccer team had this season?
4