Immuno 1
Immuno 2
Immuno 3
Hematopoiesis
porphyrias
Poryphyrias
100
___________ can bind all biomolecules, _____________ can only bind protein peptides
BCRs, TCRs
100
autoimmune hemolytic anemia is an example of a _____________ HS reaction
What is type II?
100
absent B cells in peripheral blood, low/absent Ig of all classes leads to recurent bacterial infections and enteroviral infections after 6 mons
What is X-linked agammaglobulinemia (XLA)?
100
these are the cells from the myeloid progenitor line
What are
1. RBCs
2. granulocytes
3. phagocytes
4. megakaryocytes?
100
gene defect in ALA-synthase
What is hereditary sideroblastic anemia?
100
porphyria cutanea tarda is the most common porphyria that is caused by a defective ______________________ enzyme
What is uroporphyrinogen decarboxylase?
200
NK cells = CD___
CD16
200
naive T cells require __________ for activation whereas memory T cells d not
What is CD28?
BONUS: How does CD80/86 interact with CD28?
200
heterogenous immune disorer characterized by recurrent sinopulmonary infections that occurs due to defective B cell differentiation into plasma cells
What is CVID?
200
hematopoiesis is highest in the ________ & ________ in the prenatal period
What are yolk sac and liver?
200
lead poisoning interferes with _________ and ____________ (enzymes)
What are ALA-dehydratase and ferrochelatase?
200
these are the two most common symptoms seen in porphyria cutanea tarda
What are cutaneous blistering and photosensitivity?
300
CD4+ cells are induced by __________ to become Th1 cells which secrete ___________
IL-12, IFN-y
300
CD4+ cells are induced by ___________ to become Th2 cells which secrete _______________
IL-4
IL-4, 5, 13
300
negative selections ensures that TCRs are not self-reactive and is promoted by this enzyme which turns ont he epxression of proteins from a variety of tissues
What is AIRE?
300
_________ is responsible for the production and differentiation of megakaryocyte precursors and regulation of platelet production
What is TPO?
300
_______ activates CD8+ cells, induces Ig secretion, and stimulaties eosinophils
What is IL-5?
300
acute intermittent porphyria is due to a defective ________________ enzyme
What is porphobilogen deaminase?
400
CD4+ T cells are induced by ____________ to become Th17 cells which secrete ______________
TGF-B, IL-6, IL-23
IL-17, 21, 22
400
________ present endogenous antigens from inside the cell whereas ________present exogenous antigens
MHCI, MCHII
400
low levels of low-affinity Ig due to presence of some abnormal B cells that survive development; no other Ab classes present and antigen specific antibodies cannot be made
What is SCID?
400
____________ facilitates B-cell differentiation, promotes Ig secretion, acts as growth factor for malignancy plasma cells, works with other ILs
What is IL-6?
400
difference in shape of erythrocytes
What is poililocytosis?
400
these are the treatments for PCT
What is phlebotomy and low dose hydroxychloroquine?
500
special type of rejection where donor T cells damage host tissues
What is GvHD?
BONUS: What type of HS is this?
500
activates MACs and CD8+ T cells to kill phagocytosed intracellular microbes
What are Th1 cells?
500
defect in PIGA gene preventing formation of GPi anchors for complement inhibitors?
What is PNH?
500
these are the 3 phases that occur in the developmental pathway of RBCs
1. ribosome synthesis
2. Hb accumulation
3. ejection of nucleus
500
these are the 5 P's of acute intermittent porphyria
What are
1. painful abdomen
2. port wine-colored urine
3. polyneuropathy
4. psychological disturbances
5. precipitated by drugs (CYP P450 inducers, alcohol, starvation)
500
these are the therapies/treatments for lead poisoning
What are
1. oral succimer w/ or w/o IV EDTA
2. IM dimercaprol ?