Immuno Week 8

Antibodies

100

IgA is mostly located here.

What is mucous of the GI, respiratory, and reproductive tracts? (Also milk and tears)

200

This is the majority of immunoglobulins found in serum.

What is IgG?

300

This antibody plays an important role in allergic reactions.

What is IgE?

400

This is the type of antigenic determinant that an animal is experiencing when they are given a serum injection from another species.

What is an isotypic antigenic determinant? 

500

This antibody is always found as a pentamer in serum, and contains this many binding sites.

What is IgM with 10 binding sites.

Misc

100

These are the 4 events included in the lag time of a humoral immune response.

What are clonal selection, clonal expansion, differentiation, and production of antibodies?

200

This is where an antigen travels when it enters the blood, and when it enters from external structures, respectively.

What are spleen and lymph nodes?

300

This event occurs in the light zone when the BCR undergoes small mutations.

What is affinity maturation?

400

The first responding antibody to a primary immune response is...

What is IgM?

500

The two types of cells that an activated B cell can become:

What is plasma cells and memory cells?

Misc

100

These cytokines trigger iostype switching to IgG, IgE, and IgA, respectively.

What are IFN-gamma, IL-4, and mucosal tissue cytokines?

200

These antibodies were formed by combining myeloma cells with plasma cells in a lab.

What is monoclonal antibodies?

300

This is one of the functions of antibodies, where they cause particles to clump together.

What is agglutination?

400

What does a T-independent response to an antigen create?

Weak immune response with mainly IgM and no memory cells.

500

This type of immune response relies on the presense of memory B cells and T-helper cells to produce a faster, larger response.

What is a secondary immune response?

Misc

100

What are the 2 interactions between cells that occur in the extrafollicular sites?

T cell can re-stimulate the B cell: early isotype switching
B cell can activate the T cell and produce Follicular helper T-cells.

200

Where plasma cells and memory B cells are produced.

What is the germinal center?

300

This is the main job of a plasma cell.

What is: to produce antibodies?

400

This type of chain determines what kind of antibody the B cell is producing.

What is an H chain?

500

These are the 2 main functions of antibodies:

1. Bind to a foreign antigen within a host.

2. Mediate effector functions that lead to the antigen's elimination.

Misc

100

This is when an antibody binds to a cell, then an NK cell binds to that antibody and is signaled to kill the target cell. (Bonus: what does NK release?)

What is ADCC: antigen-dependent cellular cytotoxicity? Also, what are perforins and granzymes?

200

What is the function of poly-Ig receptors?

Transports IgA and IgM through the epithelial cells.

300

This is added onto IgA antibodies in order to secrete them into the mucous (and make sure they don't get murdered).

What is a secretory component?

400

Cytopoint is this kind of antibody and it neutralizes this interleukin.

What is a monoclonal antibody? And IL-31.

500

What can the Fc region of antibodies bind to and what is the purpose of them binding (what are their cause/functions)?

Binds to Fc receptors. 

Functions: Transcytosis, mediate phagocytosis, and ADCC