The following cells are degranulated in response to IgE:
a) mast cells
b) basophils
c) macrophages
d) all of the above
e) A & B are correct
What is 'e) A & B are correct'
100
This T cell population is a component of peripheral tolerance.
What is 'regulatory T cells'
100
This mechanism, proposed to induce autoimmunity, is a result of viral or bacterial protein epitopes that are similar to self-components of the host.
What is 'molecular mimicry'
100
Autoreactive T cells are the only lymphocytes that can lead to autoimmune disases.
a) True
b) False
What is 'b) false'
200
This type of hypersensitivity is mediated by immune complex.
What is 'Type III'
200
Several mechanisms can induce mast cell degranulation. Which mechanisms do NOT require allergen?
a) allergen cross-linking
b) antibody cross-linking
c) chemical cross-linking
d) anti-receptor antibody cross-linking
f) B & C are correct
g) C & D are correct
What is 'f) B & C are correct'
200
An antigen may be tolerogenic or antigenic based on several factors such as:
What is 'antigen dose and route of exposure'
200
Autoimmunity results from the failure of this process:
What is 'Tolerance'
200
The use of anti-CD4 monoclonal antibodies blocks or depletes all TH cells, regardless of their specificity. What is one mechanism to target autoimmune cells?
What is 'activated T cells'
300
This type of hypersensitivity involves antibody mediated (IgG or IgM) destruction of cells.
What is 'Type II or ADCC'
300
Which of the following is NOT true about the low-affinity IgE receptor:
a) It contains a C-type lectin domain
b) it is also known as CD23
c) It is composed of multiple subunits
d) It is oriented in the plasma membrane with its amino-terminus toward the cell interior
What is 'c) it is composed of multiple subunits'
300
The following factors may promote tolerance rather than immune stimulation:
a) High Ag doses
b) Ag persistence
c) Absence of adjuvants
d) low costimulation
e) all of the above
What is 'e) all of the above'
300
This type of autoimmune disease is mediated by blocking antibodies that bind acetylcholine receptors on the motor end plates of muscles, thereby blocking the binding of acetylcholine and inducing cell lysis.
What is ' myasthenia gravis'
300
In EAE, the MHC haplotype of the animal determines the ability to present autoantigens to which type of T cells?
What is 'CD4+ TH cells'
400
Complement component C3b is involved in this type of hypersensitivity reaction/s:
What is 'Type III / Immune complex mediated hypersensitivity'
400
Which of the following PTK is associated with the cytoplasmic tails of the high affinity IgE receptor and initiates tyrosine phosphorylations?
a) Lyn
b) Syk
c) Fyn
d) all of the above
What is 'a) Lyn'
400
THis type of antigen leads to apoptosis or anergy:
What is 'Tolerogenic antigen'
400
This autoimmune disease affects 0.2% of the population is caused by an autoimmune attack on the pancreas.
What is 'Insulin-dependent diabetes mellitus (IDDM)'
400
The balance between TH1 and TH2 cells is important in determining immune response to infections and disease outcomes. Which TH cell appears to favor the development of autoimmune disease?
What is 'TH1 cells'
500
This type of hypersensitivity reaction/s is/are cell-mediated.
What is 'Type IV or Cell-mediated hypersensitivity'
500
This components activated in response to IgE receptor stimulation is important for microtubular assembly and fusion of granules with the plasma membrane.
What is 'Ca2+'
500
This type of antigen induces activation and/or proliferation pf lymphocytes:
What is 'Immunogenic antigen'
500
In this type of autoimmune disease, individuals make auto-antibodies to RBC antigens resulting in RBC lysis/destruction.
What is 'Autoimmune hemolytic anemia'
500
EAE is a useful animal model for which autoimmune disease?