Immunology

Blood cells

100

At this stage of  granulocyte development, secondary granules develop and cell fate is decided

Myelocyte

200

Immature red blood cells cluster around this cell for support and growth signaling

Macrophage

300

This APC has long projections and possesses B7 allowing it to activate naive T-cells

Dendritic Cell

400

This lymphoid organ is a hemicapsule and deep crypts to increase surface area

Tonsils

500

Immature T-cells in this region face destruction following excessive binding to self antigens

Thymus medulla

Inflammation

100

This form of immunity involves recieving immune cells and proteins from another person

Passive immunity

200

The production of IL-1 requires which two internal signals

NF-kappaB and inflammasome 

300

Integrins on neutrophils strongly bind this molecule to exit the blood stream

ICAM-1

400

The presence of viral DNA activates the STING complex stimulates which intracellular signals

NF-kappaB

IRFs

500

Activated macrophages use this enzyme to produce ROS inside phagosomes

Phagocyte oxidase

Innate Immunity

100

This membrane-bound receptor is a monomer that recognizes flagellin proteins

TLR-5

200

This cytokine is secreted in virally infected mucosa and induces an antiviral state in nearby cells

Interferon-3

300

This cytosolic protein allows self antigens into the ER to bind Class 1

Transporter associated with Antigen Processing 

TAP

400

This leukocyte kills cells it contacts unless they present a functioning Class 1

Natural killer cells

500

Cell surface CD59 blocks this complement component permitting cell survival

MAC 

C9

Lymphocytes

100

Self reactive T-cells that evade destruction undergo this process resulting in suppression or death

Peripheral tolerance

200

This cancer treatment uses modified antigen receptors that contain all intracellular components required for full activation

CAR-T cell therapy

300

After TLR activation, NEMO is degraded releasing IKKb to phosphorlyate this protein releasing NF-kappaB

I-kappa-B

400

This receptor is used to regulate lymphocyte migration through lymph nodes. 

Sphingosine-1-phosphate receptor 1

S1PR1

500

These adhesion proteins are expressed on endothelial cells to home effector T-cells to the site of infection.

P- and E-selectins

Adaptive Immunity

100

This protein binds tightly to CD28 resulting in deactivation of T-cell response

CTLA-4

200

This lymphocyte subtype is specialized in killing intracellular pathogens

Th1

300

These antibodies target the variable region of another antibody

Idiotype

400

In the germinal light zone, this process ensures only cells with high binding affinity survive

Affinity Maturation

500

Class switching to IgA requires CD40 binding and this cytokine

TGF-b