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Hypersensitivity Types 2-4
Vaccines
Polyclonal and Monoclonal Ab preps
Autoimmune Diseases
Immune deficiency disorders
100
Match the reactions to the type of hypersensitivity 1. Hemolytic disease of newborns 2. skin test for cell-mediated immunity 3. arthus reaction-ex: tetanus booster muscle soreness a. type 2 b. type 3 c. type 4
1. a 2. c 3. b
100
1._______ vaccines are relatively stable, don't need a cold chain for transport, and are thought to be safe to administer to immunocompromised people. 2. _______ vaccines are unstable, need cold chain for transport, and are prone to revert to virulent form if administered to immunocompromised.
1. killed/inactivated 2. live attentuated
100
You are working in a NICU. There are 2 neonates who need polyclonal antibody preparations. Phil was born premature and has tested postive for Group B Strep. Lill was born at term to a mother with an active Hep B infection. What would be the appropriate preventative treatment for each?
Phil-human immune serum globulin (IVIG); Lill-Specific human immune globulin (HBIG)
100
Which of the following diseases is not caused by the immune response cross-reacting with both foreign antigens and self tissues? a. sympathetic ophthalmia b. rheumatic fever c. ankylosing spondylitis d. guillian-barre syndrome
a. sympathetic ophthalmia- this is caused by unmasking antigens(in a normally immunologically privilaged site: the eyes) that become targets of the immune system. Tip: Remember the diseases caused by molecular mimicry via R.A.G. R-rheumatic fever, A-ankylosing spondylosis G-guillian-barre.
100
What is the most common primary immunodeficiency? a. severe combined immunodeficiency b. digeorge syndrome c. IgA deficiency d. hereditary angioedema (deficiency in C1)
What is c. 1 in 700 people.
200
Which of the following is false concerning hemolytic disease of newborns? a. it results from fetal RBC destruction b. it is a type 2 hypersensitivity reaction c. it is more likely to affect the first born d. RhoGam may be used as a preventative therapy because it binds fetal RhD+ RBC's and removes them from maternal circulation.
What is c.
200
Which of the following vaccines is NOT a killed/inactivated vaccine? a. influenza b. hepatitis a c. meningococcal d. intramuscular poliovirus
What is c. I remember the killed/inactivated vaccines via Kelly RIPA ("R"abies, "I"nfluenza, intramuscular "P"oliovirus, hep "A". K in kelly is for killed. ps. meningococcal vaccine is a purified polysaccharide capsule vaccine.
200
Which of the following is an incorrect comparison? a. monoclonal ab preps each have a single specificity for one epitope of an antigen, while polyclonal abs result from immunization or a prior infection b. SHIG is to HISG as monoclonal is to polyclonal c. most monoclonal ab preps come from human cells, while most polyclonal ab preps come from a hybridoma of 2 mouse cells. d. an example of a polyclonal ab prep is RhoGam, while an example of a monoclonal ab prep is an anti-CD3 prep to prevent transplant rejection.
What is c. Polyclonal ab preps come from humans and monoclonal preps originate from the fusion of a mouse speen plasma cell and a mouse myeloma cell. Monoclonals tend to be 90-95% humanized/chimeric, but the variable regions contain original mouse aa sequences.
200
Match the autoimmune disease to its cause: a. myasthenia gravis b. systemic lupus erythematosus c. Graves' disease d. Sjogren's syndrome(no, i don't know how to do that symbol) 1. antibodies against ACh receptors at NMJs 2. antibodies against thyroid stimulating hormone receptor, so negative feedback mech. doesn't work, so overproduction of TH results. 3. type 3 hypersensitivity rxn in which antinuclear antibodies form soluble IC w/ DNA. 4. antibodies against cytoplasmic protein-RNA complexes (SS-A & SS-B)-destroys exocrine glands
a. 1 b. 3 c. 2 d. 4
200
Match the immune deficiency to its description: a. Bruton's X-linked agammaglobulinemia b. DiGeorge Syndrome or congenital thymic aplasia c. AIDS d. SCID 1. secondary T cell immunodeficiency 2. primary T cell immunodeficiency 3. primary B-cell immunodeficiency 4. combined humoral and cell-mediated immunodeficiency
a. 3 b. 2 c. 1 d. 4
300
Which of the following is false concerning serum sickness? a. it is a type 3 hypersensitivity rxn b. it is marked by induration due to an accumulation of macrophage and lymphocytes c. serum complement levels as measured by CH50 reach lowest levels at height of disease. d. this syndrome can occur w/o prior sensitization
What is b. Induration is a hallmark of type 4 hypersensitivity.
300
Match the following vaccine types to their characteristics: a. killed/inactivated b. live attenuated c. toxoid d. polysaccharide 1. toxicity of the molecule has been removed but immunogenicity remains often using formalin 2. often T-independent antigens and needs to be joined w/ other proteins to induce immune response 3. endogenously and exogenously processed, so both an Ab and CMI response results 4. only exogenously processed & may be created using beta-propiolactone
a. 4 b. 3 c. 1 d. 2
300
Match the drug to its target: a. palivizumab b. trastuzumab c. daclizumab d. omalizumab 1. epidermal growth factor receptor (EGFR) 2. IL-2 receptor (to prevent renal allograft rejection) 3. IgE (therapy for allergies and asthma) 4. RSV F protein
a. 4 b. 1 c. 2 d. 3
300
Match the autoimmune disease to its characteristic: a. multiple sclerosis b. rheumatoid arthritis c. Graves' disease d. scleroderma 1. organ specific antibody mediated 2. systemic antibody mediated 3. T-cell mediated involving both CD4+ and CD8+ 4. systemic and both antibody and T-cell mediated
a. 3 b. 4 c. 1 d. 2
300
Which of the following is most likely to be fatal? a. reticular dysgenesis b. type 2 bare lymphocyte syndrome c. hereditary angioedema d. congenital agranulocytosis
What is a. rare but fatal because no B cells, T cells or neutrophils. Death occurs shortly after birth : (