Show:
This is "Fire"!
Relaying the Message
It's time for the "Daily Double‑Stranded RNA"
Who doesn't love a Complement?
The Trailer to the Movie
100

One of the first cells to be recruited to the site of infection; releases granules to kill the pathogen

What are neutrophils

100
Cytokines that induce fever and the acute phase proteins
What are TNF-alpha, IL-1, and IL-6
100

Intracellular sensors for microbial products that contain a nucleotide binding oligomerization domain and an LRR domain

What are NOD-like Receptors

100

This complement protein exists as a zymogen until spontaneously activated to initiate complexes on the surface of the cell

What is C3?

100

The first barrier of defense against infection

What are the skin and mucosae

200
Four characteristics of Inflammation
What are Pain (Dolor), Redness (Rubor), Heat (Calor), and Swelling (Tumor)
200
IL-6, TNF-alpha, and IL-1 beta are induced by this transcription factor
What is NF-kB
200

Sense cytoplasmic viral RNAs and induce production of type I interferons

What are RIG-I-like receptors

200

The composition of the alternative C3 convertase

What is C3bBb?

200
Examples of primary lymphoid organs

Bone marrow and Thymus

300
Movement of a phagocyte through the basement membrane
What is Diapedesis
300
Induced by viral infection and interfere with viral replication
What are the Type I interferons (IFN alpha and beta)
300

This molecule is an adaptor protein for TLR4 signaling; linking a key kinase to an intracellular signaling domain

What is MyD88

300

A protein which when released during the acute phase, binds carbohydrates on the surface of the pathogen to initiate complement signaling

What is a (mannose-binding) lectin?

300

These cells mature to produce helper cells and cytotoxic cells

What are T-lymphocytes

400

A pro-inflammatory cytokine that is made by pattern recognition receptors, and is cleaved from the pro-form by the NLRP3 inflammasome

What is IL-1 Beta

400

Prominent cytokine producer; is also a phagocyte with professional antigen presenting capabilities

What is a macrophage

400

NALP3 senses these signals in addition to PAMPs and assembles with an adaptor protein and caspase 1 to form the inflammasome

What are Damage-associated molecular patterns (DAMPs) /(cellular damage/stress)

400

The composition of the classical C5 convertase

C4b2b3b

400

The three types of professional antigen-presenting cells (APCs)

What are Macrophages, Dendritic Cells, and B lymphocytes (B-cells)

500

How leukocytes are recruited to the site of inflammation

What is (are) chemotaxis

500

The two transcription factors for Type I interferons

What are IRF3 and IRF7

500

The intracellular domain that interacts with an adaptor protein in the TLR4 signaling pathway

What is the Toll-interleukin receptor (TIR)?

500
In addition to antibody, it also binds the pathogen and initiates the classical complement pathway

What  is C-reactive protein (CRP)?

500

A key role of antibodies

What is neutralization, opsonization and complement activation