Vaccines
Trade name for subunit influenza vaccine
What is Flublok?
Antibody isotype(s) that activate complement.
What are IgM and IgG?
Effector T cell subset required for type I hypersensitivity.
What is Th2?
Molecule within the costimulation family of receptors that was characterized as a therapeutic target by 2018 Nobel Laureate James Allison. Medications targeting this molecule, such as ipilimumab, are approved for melanoma.
What is CTLA-4?
Probability of being HLA-matched with your sibling.
What is 25 percent?
Term that describes how vaccinating the majority of a population can protect immunocompromised people from getting infected.
What is herd immunity?
One blood marker that can be detected in the diagnosis of rheumatoid arthritis.
What are rheumatoid factor, anti-citrullinated peptide antibodies (ACPAs) or C-reactive protein (CRP)?
Antibody isotype required for type I hypersensitivity.
What is IgE?
Antigenic target of the monoclonal antibody Nivolumab (Opdivo). The gene encoding this receptor was initially characterized as protective against autoimmunity by 2018 Nobel Prize laureate Tasuku Honjo, and is now known to play a central role in "T cell exhaustion."
What is PD-1?
Blood type(s) used for donating to recipients with type AB
What are A, B, AB and O?
Type of vaccine in which a live organism is injected into a person.
What is attenuated?
Enzyme responsible for protein citrullination.
What is Protein Arginine Demininase?
Mast cell chemical targeted in over-the-counter medications used to treat type I hypersensitivity reactions.
What is histamine?
Lymphocyte subset responsible for destroying tumor cells during antibody-dependent cellular cytotoxicity.
What are Natural Killer cells?
Compatibility test that determines if an organ transplant recipient produces antibodies against the donor's organ.
What is cross-matching?
One company that produces an mRNA vaccine for COVID.
What are Moderna or Pfizer-BioNTech?
How does AIRE (AutoImmune REgulator) affect lymphocyte development?
What is negative selection of T cells in the thymus by promoting the expression of tissue-specific antigens?
Two treatments for asthma that have different mechanisms of action.
What are b2 adrenergic receptor agonists, corticosteroids, leukotriene modifiers, mast cell suppressors (Cromolyn, Omalizumab, anti-histamines) and anti-cholinergics?
Tumor immunoediting stage in which variants first arise that are resistant to the immune system.
What is equilibrium?
Treatment used to prevent hemolytic disease of the newborn.
What is RhoGAM?
One vaccine adjuvant.
What are alum, ASO1B, AS04, CpG1018, MF59 or Monophosphoryl Lipid A?
One way in which infections can provoke autoimmune reactions
What is Dendritic Cell maturation or Molecular Mimicry?
Cell type that causes tissue damage during type IV hypersensitivity reactions.
What is macrophage?
One of the hallmarks of cancer is "Avoiding immune destruction." Describe how cancers can accomplish this.
What are expressing immunosuppressive molecules (PD-1, TGF-b), decreasing antigen expression or mutating antigens?
Class of drugs used for induction therapy in transplantation.
What are monoclonal antibodies?