Defining Cytokines
CD4+ Th2
IL-4, IL-5, IL-13
TH1
What is T-bet?
The co-receptor for MHC class I
What is CD8?
The process by which the CD8+ effector response starts but is shut down
What is exhaustion?
Injury/inflammation caused by a T-cell mediated reaction
What is delayed-type hypersensitivity?
CD8+ CTL
What is IFN-gamma?
Th2
The co-receptor for MHC class II
What is CD4?
Name at least two functional defects in T-cell exhaustion
What are decreased proliferation, decreased production of INF-gamma, and poor cytotoxic activity?
The principal target cells of effector CD4+ Th1 cells
What are macrophages?
CD4+ Th17
What is IL-17 and IL-22?
Th17
What is ROR-gt?
The ligand for LFA-1 (which is on the CTL surface) on the target cell surface.
What is ICAM-1?
Name the two CTL populations found after clearance of an acute viral infection.
What are effector and memory CD8+ T lymphocytes?
This ligand-receptor interaction results in activation of caspases and apoptosis
What is FasL-Fas receptor?
CD4+ Tfh
What is IL-21
Treg
What is FOXP3?
Shared by NK cells, CTLs express these receptors that send inhibitory signals to prevent killing of normal cells
What are killer immunoglobulin receptors (KIRs)?
Identify a persistent infection that may be related to T-cell exhaustion
Membrane-poring protein homologous to C9 complement
What is perforin?
NKT cells
What is IL-4 and IFN-gamma?
Tfh
What is Bcl-6 and IRAF-4?
This CTL receptor recognizes class I-like MHC molecules MIC-A, MIC-B, and ULBP expressed on stressed cells
What is NKG2D?
Name at least one inhibitory receptor expressed on exhausted CTLs.
PRF1, UNC13D, STX11, STXBP2