Acute inflammation
We are the cells that love to eat :P (professional phagocytes)
what are Dendritic cells, macrophage, monocytes, neutrophils
Vascular dilation is important because...
what is it increases blood flow thus increases immune cell trafficking
the 4 PRR families
what is CLRs, NLRs, RLRs, TLRs
3 complement pathways and what they recognize
what is
lectin: carbohydrates
classical: antibodies
alternative: always active
Where T and B cells are activated and find their cognate antigen.
what is the lymph node
we are granulocytes
neutrophils, basophils, eosinophils and mast cells
immune cells perform these actions to extravasate into the tissue.
what is rolling and crawling (tether & slinging)
I recognize viral RNA
what is RLRs
we are the pro inflammatory cytokines
IL-6, TNF, IL-1
the main difference between BCR and TCR presentation
what is
BCR --> whole antigen and TCR --> peptide of antigen via MHC
I am a type of macrophage that has enhanced phagocytosis and increased MHC2 expression
what is M1
I am essential for rolling during extravasation
what is Selectin
the main transcription factors activated
what is NfKB, AP-1 and IRF
we are the anti-inflammatory cytokines
what is IL-4, IL-10 and TGF b
resolution mediators
nitric oxide, IL-10 and phosphatidyl serine
3 types of phagocytosis
what is
1) zipper
2) sink
3) coiling
We are essential during crawling (tether & sliding)
what is integrins and chemokine
we are the cytosolic PRRs
TLRs and RLRs
I use jak/stat signaling
what is IL-6
inflammation is not resolved
damage, fibrosis and scarring
we are the 3 types of immune response
what are
Type 1: intracellular
Type 2: extracellular worms
Type 17: extracellular pathogens
directional movement following a gradient.
what is chemotaxis
walk through how the inflammasome is formed
what is
1) NfKB activation
2) oligomerization of NLRs
3) adaptor proteins (Caspase-1)
4) cascade-1 cleaves pro-IL-1b
5) cascade cleaves gasdermin
6) pores form
the reason why chemokine can bind to cells
what is the charge. chemokine are positive and parts of the cell surface are negative
what are the steps of resolution of inflammation
what is
1) stop new immune cell influx
2) counter inflammatory mediators
3) kill recruited leukocytes
4) reprogram macrophage
5) leave site (immune cells)
6) inform adaptive immune response
7) heal