Mediators
What cells are responsible for synthesizing complement?
What are hepatocytes
What are the three main components of the inflammatory response?
What are cellular components
What are vascular components
What are chemical mediators
Give an example of a physical barrier in innate immunity
What is skin
What is the epidermis
What is mucous
What are mucosal membrane surfaces
What is hair
What is saliva
Which leukocyte is most commonly seen in the innate response?
Give 3 examples of chemotactic mediators
What is C3a
What is C5a
What is TNF-a
What are lipoxygenase products (LTB4)
What are formylated peptides
What is IL-1
What are chemokines
What are the 5 signs of inflammation
What is redness
What is swelling
What is heat
What is pain
What is loss of function
What structure could be found on the surface on an epithelial cell that helps to trap microbes
What are cilia
Which cell is mainly responsible for bridging the innate and adaptive responses?
What is the Dendritic Cell
Give 3 examples of vasoactive mediators
What is histamine
What are leukotrienes
What are prostaglandins
What is bradykinin
What is substance P
What is serotonin
What is nitric oxide
What is platelet activating factor
What are the two classes of enzyme responsible for the different arachidonic acid metabolites?
What are cyclooxygenases
What are lipoxygenases
Give one example of how saliva protects the body from pathogens
What are IgA antibodies
What is entrapment of microbes
What is lysozyme
What is lactoferrin
Give two examples of the roles phagocytes may have in the innate immune response
What is the elimination of pathogens
What is the clearance of cell debris
What is antigen presentation
What is cytokine production
What are the 3 main outcomes of complement activation? What are these outcomes responsible for?
What is activation of C3a and C5a (Chemotactic, Proinflammatory)
What is activation of C3b (Opsonising microbes)
What is formation of the membrane attack complex (Lysis of microbes)
What force is reduced during acute inflammation that results in an increased net flow of fluid out of vessels and into tissues
What is colloid osmotic pressure
How does deep fascia contribute to protection against disease?
What is compartmentalisation of muscle
What is the prevention of spread of infection from skin and superficial fascia to muscle compartments
What is the prevention of neoplastic spread
What are the two main pathways that NK cells use to trigger the caspase cascade and induce apoptosis?
What is Porin + granzymes
What is the Fas Ligand