Recognition
Which receptors detect PAMPs?
PRRs
What do neutrophils create when they release their nuclear content?
NETs or Neutrophil Extracellular Traps
What is inflammation?
Response when immune and local tissue cells detect injury or infection.
Why does vasodilation cause redness at an inflamed site?
Increased blood flow to the area
What does TLR stand for?
Toll Like Receptors
What organelle forms to kill microbes?
Phagolysosome
Main roll of cytokines
Communication between Immune cells
What term describes an elevated body temperature caused by cytokines?
Fever
Receptors that sense signals from stressed/ damaged host cells?
DAMPS
What cells are Phagocytes?
Neutrophils, Monocytes, Macrophages, & DC
Name two cytokines that cause fever
IL-1, IL-6, TNF-α
Pathogen Associated Molecular Patterns
Which innate immune cell is most important for linking the innate and adaptive immune systems?
Dendritic cells
What liver protein binds mannose residues on pathogens to activate complement?
Mannose-binding lectin
What interferons are secreted after viral RNA recognition to protect nearby cells?
Type I Interferons
After engulfing a pathogen a phagosome fuses with what to form a phagolysosome?
Phagolysosome
What condition occurs when inflammation becomes widespread and dysregulated, leading to organ damage?
Sepsis