Skin Deep
Pruritic papules and plaques on upper thighs and abdomen with umbilical sparing; spares arms
What is Polymorphic Eruption of Pregnancy? (previously known as Pruritic Urticarial Papules and Plaques of Pregnancy)
This risk factor is associated with a recurrence rate of 60-70%
What is prior history?
Commonly ordered labs for evaluation
What are Total Bile Acids and LFTs/CMP?
First-line therapy for ICP
Ursodiol
This bile acid level is associated with the highest risk of stillbirth.
What is >/=100 mmol/L?
Pruritus without physical rash associated with increase in various serum laboratory values
What is Intrahepatic Cholestasis of Pregnancy?
What is Hepatitis?
Frequency of antenatal testing performed as recommended by ACOG
Twice weekly
Commonly used medication to decrease symptoms without affecting bile acids
What are antihistamines?
Gestational age at which delivery is first recommended if patient has bile acids <40
What is 37 weeks?
Erythematous vesicles and bullae that may cause severe blistering
What is Pemphigoid Gestationis?
This risk factor may be associated with the need for a future surgery
What is Cholelithiasis/Cholecystitis?
What is 10 mmol/L?
Decreases secretion of cholesterol from liver and the fractional absorption of cholesterol by the intestines
Ursodiol
Gestational age at which delivery is first recommended if patient has bile acids >40
What is 36 weeks?
Eczematous rash on face/neck, trunk and FLEXOR surfaces of limbs
What is Atopic Eruption of Pregnancy?
What is Pancreatitis?
The risk of stillbirth is thought to be caused by ________
What is the development of a fetal arrhythmia?
What is vasospasm of placenta chorionic surface vessels?
Decreases ileal absorption of bile salts, thereby increasing fecal excretion
Gestational age at which delivery is first recommended if patient has a clinical diagnosis
What is 37 weeks?
What is Prurigo of Pregnancy?
Associated with many other pregnancy complications, this risk factor may not make patients feel ahead of the curve.
What is Advanced Maternal Age?
This mechanism is thought to be the cause of increased risk of spontaneous preterm labor in patient with ICP.
What is the increased expression of myometrial oxytocin receptors by bile acids?
Increases biliary excretion of hormone metabolites
What is S-Adenosylmethionine?
Delivery is first recommended at 34 weeks if patient has bile acids >100 and __________
What is excruciating/unremitting pruritus?
What is history of ICP associated stillbirth <36 weeks in a prior pregnancy?
What is a pre-existing/acute hepatic disorder with evidence of worsening hepatic function?