Tumor Basics
The term used to describe the type of tumor whose ancestor is a single cell type.
Monoclonal tumor.
A virus that contains an RNA genome. Eg. RSV.
What is a retrovirus?
Form of retinoblastoma that usually involves an inherited mutant allele.
What is bilateral retinoblastoma?
Expressed by T-cells, when bound by CD80 inhibits T-cell activation.
What is CTLA4?
Chemical produced by corn lily, that inhibits Smoothened.
What is cyclopamine?
This is the quiescent stage of the cell cycle.
G0
The term given to enzymes that are constantly active, as seen in oncogenes.
What is constitutive activity?
What is EMT?
Express MHC molecules to display tumor specific antigens.
What are antigen presenting cells?
Malformation resulting in cyclops eyes and other mutations in the head region.
What is Cycloplegia?
A tumor suppressor gene with a higher copy number in larger animals compared to humans.
What is TP53?
Commonly referred to as molecular switches the genes for these proteins are frequently oncogenic.
What are GTPases?
What is hyperphosphorylated Rb?
The antibody against CTLA4.
What are ipilimumab?
Area of the brain where cancer resulting from excess sonic hedgehog signaling occurs.
What is Cerrebellum?
It's the name of the clumps that transformed cells make when grown in culture.
What is a focus (foci)?
The discovery of this enzyme overturned the central dogma of molecular biology.
What is reverse transcriptase?
A mutation that occurs when one copy of a gene is lost.
What is loss of heterozygosity (LOH)?
Process for maximal T-cell activation.
What is two step activation?
Transcription factor that is activated by hedgehog pathway.
What is Gli?
What is histidine?
The gene found in RSV but not ALV.
Antigen to which most CART cells are engineered to target.
What is CD19?
Twelve transmembrane receptor that inhibits Smoothened
What is Patched?