Toxins
Antidotes
Toxidromes
Enhanced Elimination
Toxidromes/Antidotes
100

Antidote for Cocaine induced sympathomimetic syndrome

Benzodiazepines (Clonidine also acceptable)

(Phentolamine for myocardial ischemia, sodium bicarbonate or lidocaine for ventricular dyssrythmias)

100

N-acetylcysteine

Acetaminophen

100

Bradycardia, hypotension, hypoglycemia.

beta blocker

100
Ingestion of extended release preparations, body packing, and heavy metal ingestion may all be indications for this enhanced elimination technique

Whole bowel irrigation

100

somnolent, miosis, respiratory rate 10.

naloxone

200

Antidotes for calcium channel blocker toxicity

Calcium

high dose insulin

200

Oxygen

Carbon monoxide

200

20 year old male with agitation, noted to be "picking at things in the air." His heart rate is 120 with blood pressure 145/90. Pupils are dilated and skin is dry and flushed.

Coricidin - acetaminophen/chlorpheniramine. (benadryl, hydroxyzine would also be acceptable)

200

Metformin toxicity causes severe lactic acidosis and tends to be responsive to this enhanced elimination technique

Hemodialysis

200

56 year old white male went to the barn to "work on the tractor." When he returned, he appeared intoxicated. pH is 7.02 with an anion gap metabolic acidosis on CMP and an osmolar gap of 35.

Fomepizole

300

Most concerning toxicity of Wellbutrin

Seizure

300

1U/kg Insulin infusion

Beta blocker (calcium channel blocker also acceptable)

300

64 year old female with history of congestive heart failure is found with pills around her bed. On ekg patient is found to have frequent pvc's and her initial whole blood potassium is 6.0.

Digoxin

300

carbamazepine, phenobarbital, theophylline, salicylates, and tricyclic antidepressants may all be indications for this enhanced elimination technique

multi-dose activated charcoal

300

25 year old female with an unknown ingestion. She demonstrates altered mental status. Vs: p 110 bp 130/80 r 24 sao2 95% on ra. ABG: 7.44/26/113/18

Sodium Bicarbonate

400

Antidote for seizures related to isoniazid

pyridoxine

400

cyproheptadine +/- olanzapine

serotonin syndrome

400

25 year old female with depression presents with 3 hours of wildly uncontrollable behavior. VS: P=124 BP = 152/110 T=39.5 R=22 SaO2=95% on RA. Pt.'s friend reports that they went clubbing and she suspects her friend may have used something. Physical exam reveals hyperreflexia, inducible clonus, and ocular clonus.

PCP (cocaine also acceptable)

400

This enhanced elimination technique is used in mild to moderate severity salicylate toxicity

Urinary alkalization

400

syncope after involvement in a structure fire. Lactate 10.

hydroxylcobalamine (amyl nitrate and sodium thiosulfate also acceptable)

500

Antidote for valproic acid toxicity

L-carnitine

500

Atropine/Pralidoxime

Organophosphate

500

16 year old amish female presents with generalized weakness, mild confusion, dyspnea, and a bluish tint to the lips and skin. Pulse oximetry reveals an oxygen saturation of 85%.

Nitrates in well water causing methemoglobinemia

500

30 year old male presents to ED, vs: p 130, bp 85/50, r 20, sao2 95% on ra. On exam, pupils are dilated, skin is dry, and patient has hypoactive bowel sounds. ECG shows wide complex tachycardia at a rate of 110.


Sodium Bicarbonate