Fungi
Yeasts reproduce via __________.
What is budding or fission?
Echinocandins are only available to administer via what route?
What is intravenous (IV)?
Candidemia is defined by the presence of Candida in which sterile body site?
What is the bloodstream?
Aspergillosis typically affects this organ system.
What is the lower respiratory tract/lungs?
This azole agent is rarely used systemically due to heightened risk of nephrotoxicity.
What is ketoconazole?
Aspergillus is an example of a ________.
What is mold?
Amphotericin B formulation that is associated with less risk of nephrotoxicity.
What is liposomal or lipid complex Am B?
FIRST-LINE agent for treatment of candidemia. (Multiple acceptable answers)
What is micafungin, caspofungin, or anidulafungin?
Drug of choice for treatment of Aspergillosis.
What is voriconazole?
Azoles mechanistically inhibit the synthesis of what fungal cell wall component?
What is ergosterol?
True of False: fungi generally grow quickly and culture results are easy to collect.
Preferred antifungal agent in pregnant patients.
What is amphotericin B?
Treatment duration for candidemia.
What is 14 days after blood culture clearance and symptom resolution?
Typical treatment duration of consolidation phase for cryptococcal meningitis.
What is 8 weeks?
Black box warning associated with itraconazole: increased risk of _________ _______________.
What is heart failure?
Type of mycosis that typically develop in immunosuppressed patients.
What are opportunistic infections?
Class of antifungal agent that rarely develop resistance due to a unique mechanism that only affects fungal cells.
What are echinocandins?
Oral treatment option for symptomatic Candida UTI.
What is fluconazole?
This azole agent is particularly useful for treating infections caused by endemic molds (Histoplasmosis/Blastomycosis).
What is itraconazole?
Azole agents have significant drug interactions, largely due to inhibition of this common CYP enzyme.
What is CYP 3A4?
Dimorphic fungi grow as ____________ at normal body temperature.
What are yeasts?
Black box warning for amphotericin B: Verify product name and dosage to avoid _______.
What are dosing errors?
Preferred treatment option for a candida infection of the central nervous system (CNS).
What is liposomal AmB (+/- flucytosine)?
What is lumbar puncture (LP) with cerebrospinal fluid (CSF) analysis?
Azole agent that is associated with QTC SHORTENING.
What is isavuconazole?