Penicillins
Penicillins target what molecule?
PBP (Penicillin Binding Protein)
True or False: Cephalosporins are a Beta Lactam
True or False: Third generation quinolones are given once daily.
True
True or False: Aminoglycosides are commonly given orally (PO).
False, they are cationic (causes low gut absorption) and usually IV
How does Bactrim (SMZ/TMP) work?
Inhibition of Folate Synthesis
What is the class of drugs commonly combined with Penicillins and nicknamed "Trojan Horses"
Clavams or Beta Lactamase inhibitors.
In general, the higher the generation of a cephalosporin the more activity it has toward what type of bacteria? (+ or -)
Gram(-) Bacteria
What is the racemic version of Levofloxacin called?
Ofloxacin
Aminoglycosides bind to and inhibit what?
30s subunit on the bacterial ribosome?
What antibiotic mimics PEP which prevents cell wall biosynthesis?
Fosfomycin
What Penicillin is known as the Bazooka and has very broad coverage of both Gram(+) and Gram(-) bacteria?
Piperacillin
Cephalosporins contain a cross-reactivity reaction with what other class of antibiotics?
Penicillins
Quinolones work by inhibiting what molecule?
DNA gyrase
Aminoglycosides alone are better at fighting what kind of bacteria? (+ or -)
Gram(-) bacteria, have a hard time getting through thick peptidoglycan wall.
Which Carbapenem requires coadministration with Cilastatin
Imipenem
Penicillins can have strong hypersensitivity reactions due to formation of what during breakdown?
Hapten Formation
What is the only 3rd generation Cephalosporin that has Pseudomonas activity?
Ceftazidime
What chemical moiety in some quinolones binds to GABA receptors?
Piperazinyl
Give two extreme side effects of Aminoglycosides
Ototoxicity, Kidney Tubular Necrosis, Rare Neuromuscular blockage
Ertapenem
What version of the Penicillin Binding Protein does MRSA have?
PBP2a
What cephalosporin works against PBP2a?
Ceftaroline fosamil (Teflaro)
Which Quinolone doesn't contain a Fluorine?
Nalidixic Acid
What Aminoglycoside is derived from Sisomicin?
Plazomicin (Zemdri)
What antibiotic contains a NO2 group and can turn the urine brownish
Nitrofurantoin