Pop Star Pharmacology
This class of drugs includes propofol, known for sedating patients quickly.
What are general anesthetics?
Prolonged hypoxia from overdose may result in this swelling of the brain.
What is cerebral edema and brain injury
This doctor was found guilty of involuntary manslaughter in MJ’s death.
Who is Dr. Conrad Murray?
This is the medical term for complete cessation of breathing.
What is apnea?
When combined with this class of drugs (like lorazepam), propofol’s sedative effects are dangerously enhanced.
What are benzodiazepines?
This vital function is usually the first to fail when too much propofol is administered.
What is spontaneous breathing (respiratory drive)?
This diagnostic tool is the most helpful in confirming respiratory acidosis in this scenario
What are arterial blood gas (ABG)?
Dr. Murray served this many years in prison after being convicted.
What are 2 years (out of a 4-year sentence)?
This blue discoloration of the skin signals poor oxygenation.
What is cyanosis?
This is the most important intervention immediately after giving too much propofol.
What is airway support (or initiate bag-valve-mask ventilation/CPR)?
This the most immediate life-threatening effect of a Propofol overdose?
What is central respiratory depression?
This is the typical cardiovascular response to a high dose of Propofol.
What is bradycardia and hypotension?
In legal terms, Dr. Murray was not charged with murder, but with this lesser offense.
What is involuntary manslaughter?
In respiratory acidosis, blood pH shifts in this direction.
What is lower (becomes acidic)?
Propofol acts within this many seconds when given IV.
What is 30 to 60 seconds?
This neurotransmitter is enhanced by propofol to cause sedation.
What is GABA (gamma-aminobutyric acid)?
This part of the brain is directly affected by Propofol to reduce respiratory drive
What is the brainstem (medulla oblongata and pons)?
This legal term describes when a provider knowingly ignores a substantial risk to a patient’s safety.
What is reckless endangerment?
CO₂ buildup in the blood due to poor breathing is known as this condition.
What is hypercapnia?
Propofol should always be administered with this type of airway and heart monitoring.
What are pulse oximetry and cardiac monitoring?
Propofol is white, has a milky appearance and memory-erasing effect giving it the nickname _.
What is the "milk of amnesia"?
During propofol overdose, decreased oxygen delivery to tissues causes this form of shock.
What is hypoxic (or distributive) shock?
This ethical principle means acting in the best interest of the patient.
What is beneficence?
Without oxygen, cells switch to this less efficient energy-producing process.
What is anaerobic metabolism?
Propofol has a very short half-life because it is rapidly metabolized in this organ.
What is the liver?