Experimental Design/Methods
The total duration of the feeding intervention.
What is 16 weeks?
This hormone decreased significantly with intermittent fasting in diabetic mice.
What is Insulin?
Where are the β cells found in the body?
What is the Pancreas?
Intermittent fasting reduced the size of these pancreatic structures without impairing function.
What are islets (or islets of Langerhans?)
What is the difference between KK and KKAy mice?
What are:
KK mice develop moderate T2DM
KKAy mice develop severe T2DM and obesity
What fasting/feeding schedule were the KK-IF and the KKAy-IF mice exposed to?
What is 24 h fasting/24 h feeding AL diet cycles for 16 weeks?
β-cells are located in these pancreatic micro-organs.
What are islets of Langerhans?
This group showed the most improvement in insulin sensitivity with intermittent fasting.
What is KKAy-IF?
This mouse strain served as the healthy, non-diabetic control group
What is C57BL/6J?
IF improved this measure of glucose regulation that involves injecting glucose.
What is the Glucose Tolerance Test (GTT)?
How does T2DM impact β-cell mass and shape?
What is loss of mass and identity of the β-cells, as they become overworked and lose their function?
What did the study identify as a potential alternative to pharmacological approaches to T2DM treatment?
What is Intermittent Fasting (IF)?
This imaging technique was used to assess tissue structure and protein expression.
What is Immunohistochemistry?
IF reversed this fat-related liver condition.
What is hepatic steatosis?
Despite having smaller islets, IF mice showed improved secretion of insulin in response to this stimulus.
What is Glucose?
IF increased the expression of β-cell transcription factors. Name at least two out of the three.
What are NKX6.1, MAFA, or PDX1?