category 1
Where is the CYP complex located in the cell?
ER
A compound which contains 2 or more chiral centers and is optically inactive due to an internal plane of symmetry
The most important organ involved in drug metabolism
Liver
What is the most important Phase II reaction?
Glucuronidation
What is James Bond's code name?
007
Oxidative deamination occurs only with ___________
aliphatic amines
What are the three possible pathways for Phase I drug metabolism?
Oxidation, Reduction, and Hydrolysis
Oxidation of aromatic compounds generates _______
Phenols
The measure of how much drug binds to the receptor at any given concentration
Affinity
M&M’S Fruit Chews would eventually become what popular candy?
Starburst
In Phase II drug metabolism, acetylation and methylation typically lower ________________
water solubility
View down the bond of interest, front carbon represented by a "dot" is proximal; back carbon is represented by a circle and is distal
Newman projection
What is the relationship between ephedrine and pseudoephedrine?
They are diastereomers
the amount of drug required to achieve any given response
potency
What was the first animal ever to be cloned?
A sheep
Used to raise blood pressure, dilate the bronchi and pupils, and contract capillaries on mucous membranes
Ephedrine
An inactive parent drug that is activated through metabolism
Prodrug
The administered form of a drug
Parent drug
the measure of the drug effect; magnitude of response resulting from formation of a drug-receptor complex
Cillian Murphy plays a 1900s mob boss in Birmingham, England in which streaming series?
A compound that is foreign to the body
Xenobiotic
What is Le Bel-van't Hoff Rule?
number of stereoisomers of an organic compound containing no internal planes of symmetry is 2^n, where n represents the number of chiral carbon atoms
What are the 3 factors that influence conformational isomerism?
1. Steric or van der Waals repulsion
2. Charge or electrostatic interactions
3. Hydrogen bonding
What two factors dictate where aromatic hydroxylation occurs in Phase I metabolism?
electron density and sterics
What name is singer-actor Stefani Germanotta better known by?
Lady Gaga