Context
What is the name of the flesh eating bacteria?
Capnocytopaga Canimorsus (C. Canimorsus or Cc5)
What is the mutant gene?
SiaC.
T/F: The bacteria is extremely inefficient in capturing the amino sugars
False: It's extremely efficient
What type of bacteria is C. Canimorsus?
It is a gram-negative bacteria.
What were the results of the research experiment with Cc5?
Growth of C. canimorsus 5 requires direct contact with cells
Most probably evolved as a _______ factor
adaptation/mutation
What is one symptom a severe infection could include?
Aseptic Shock or inflammation or respiratory issues or fevers
Growth could be restored by ______ recombinant siaC or NanH.
Purified
What is the role of sialidase?
Provides access to sugars of surface-exposed glycoproteins. (Allows bacteria to "eat")
What 'fitness factor' did the bacteria gain?
The factor to devour phagocytes through deglycosylation.
What is the hypothesis for the bacterial experiment?
The dependence of direct contact with mammalian cells for C. Canimorsus to due to surface exposed sialidase.
What is LPS or polysaccharide?
Structure protects C. Canimorsus from MAC and from efficient phagocytosis