Jeopardy!!!

Cardiovascular System

5

Which of the following is contra-indicated in patient with Hypertension and Diabetes mellitus?

a) Lisinopril

b) Amlodipine

c) Propranolol

d) Telmisartan

Propranolol

10

Class III anti-arrhythmic agents primarily exert their cardiac actions by blocking which of the following currents?

A) Inward Na current

B) Outward K current

C) L-type Ca current  

D) Pacemaker current 

Outward K current

15

Which of the following electrolyte imbalances is most commonly associated with digitalis toxicity?

A) Hyperkalemia

B) Hypokalemia

C) Hypernatremia

D) Hyponatremia

Hypokalemia

Central Nervous System

5

Which of the following anti-epileptic drugs acts by blocking voltage-gated sodium channels in their inactivated state?

A) Vigabatrin

B) Phenytoin

C) Ethosuximide

D) Diazepam

Phenytoin

10

Which intravenous anesthetic agent is contraindicated in patients with acute intermittent porphyria?

A) Etomidate

b) Thiopentone

c) Propofol

d) Ketamine

Thiopentone

15

Which of the following neurochemical changes is responsible for lowering seizure threshold in bupropion therapy for depression?

A) High-affinity antagonism at central GABA-a receptor chloride channels

B) Accumulation of synaptic dopamine and norepinephrine leading to excessive firing of excitatory networks

C) Potent uncoupling of neuronal Na/K-ATPase pumps in the hippocampus

D) Blockade of presynaptic alpha2-adrenergic autoreceptors triggering a catecholamine storm

Accumulation of synaptic dopamine and norepinephrine leading to excessive firing of excitatory networks

Endocrine System

5

Which of the following agents can result in severe hypoglycemia?

a) Dapagliflozin

b) Pioglitazone

c) Glimepiride

d) Semaglutide

Glimepiride

10

Corticosteroid therapy should be tapered gradually mainly to prevent?

A) Hypernatremia

B) Hypoglycaemia

C) Hypotension

D) Osteoporosis

Hypotension

15

Which of the following monoclonal antibodies inhibit RANKL?

A) Romosozumab

B) Denosumab

C) Burosumab

D) Adalimumab

Denosumab

Drugs affecting Blood and formation

5

A strict vegetarian presents with megaloblastic anaemia, glossitis and peripheral neuropathy. Which therapy is most appropriate?

a) Oral folic acid

b) IM hydroxycobalamine

c) Oral hydroxycobalamine

d) Iron therapy

IM hydroxycobalamine

10

Folinic acid is specifically indicated in?
a) methotrexate toxicity

b) neural tube defect prophylaxis

c) sickle cell anemia

d) cyanide poisoning

methotrexate toxicity

15

A patient with acute DVT receives heparin. After 7 days, platelet count drops to 45,000/microlitre. Which anticoagulant is most appropriate now?

a) low molecular weight heparin

b) argatroban

c) fondaparinux

d) protamine sulfate

argatroban

General Pharmacology

5

When de-challenge and re-challenge for a drug is not done, the WHO-UMC causality assessment will be:

a) Certain

b) Probable

c) Possible

d) Unlikely

Possible

10

Which of the following fixed dose combinations show an additive action?

a) Levodopa + Carbidopa

b) Beta-lactam + Clavulanic acid

c) Sulfonamide + Trimethoprim

d) Paracetamol + Aspirin

Paracetamol + Aspirin

15

Which of the following parameters do not determine plasma steady state concentrations of a drug administered orally?

a) bioavailability

b) dose rate

c) clearance

d) half-life

half-life