Neuro & Psych
Pulmonary
Pediatrics
Endocrine
Heme/Renal
100
Clinical Vignette:
35F with new-onset headaches, nausea, and vision changes. Papilledema on exam.
Board Question: What is the most likely diagnosis? Treatment?
A. Pseudotumor cerebri
B. Meningitis
C. Idiopathic intracranial hypertension
D. Cluster headache
Correct Answer:
C - Idiopathic intracranial hypertension
Treatment:
100
Clinical Vignette:
60M with chronic cough, clubbing, and recurrent infections. CXR shows bronchiectasis.
Question: What is the most likely diagnosis? Treatment?
A. Asthma
B. Bronchiectasis
C. Tuberculosis
D. COPD
Correct Answer:
B - Bronchiectasis
Treatment:
100
Clinical Vignette:
4F with barking cough, inspiratory stridor. Steeple sign on X-ray.
Question: What is the most likely diagnosis? Treatment?
A. Epiglottitis
B. Bronchiolitis
C. Croup
D. Asthma
Correct Answer:
C - Croup (laryngotracheobronchitis)
Treatment:
100
Clinical Vignette:
50F with fatigue, cold intolerance, dry skin. TSH elevated, T4 low.
Question: What is the most likely diagnosis? Treatment?
A. Subacute thyroiditis
B. Graves disease
C. Hashimoto’s
D. Central hypothyroidism
Correct Answer:
C - Primary hypothyroidism (Hashimoto’s)
Treatment:
100
Clinical Vignette:
68M with fatigue, low MCV, positive FOBT.
Question: What is the most likely diagnosis? Treatment?
A. Iron deficiency anemia
B. Anemia of chronic disease
C. Thalassemia
D. Lead poisoning
Correct Answer:
A - Iron deficiency anemia
Treatment:
200
Clinical Vignette:
22M with worsening depression, insomnia, and weight loss. No suicidal ideation.
Question: What is the most likely diagnosis? Treatment?
A. Bipolar disorder
B. Major depressive disorder
C. Adjustment disorder
D. Schizophrenia
Correct Answer:
B - Major Depressive Disorder
Treatment:
200
Clinical Vignette:
55F with 20 pack-year smoking history, dyspnea, wheezing, productive cough.
Question: What is the most likely diagnosis? Treatment?
A. Chronic bronchitis
B. Asthma
C. Lung abscess
D. Sarcoidosis
Correct Answer:
A - Chronic bronchitis (COPD)
Treatment:
200
Clinical Vignette:
2M with fever, irritability, bulging fontanelle. LP shows high WBC and low glucose.
Question: What is the most likely diagnosis? Treatment?
A. Viral meningitis
B. Bacterial meningitis
C. Sepsis
D. Hydrocephalus
Correct Answer:
B - Bacterial meningitis
Treatment:
200
Clinical Vignette:
30F with weight gain, purple striae, moon facies. High cortisol levels.
Question: What is the most likely diagnosis? Treatment?
A. Addison’s disease
B. Cushing syndrome
C. Pheochromocytoma
D. Hyperthyroidism
Correct Answer:
B - Cushing syndrome
Treatment:
200
Clinical Vignette:
17F with hematuria after sore throat, RBC casts in urine.
Question: What is the most likely diagnosis? Treatment?
A. IgA nephropathy
B. Post-strep GN
C. HSP
D. Minimal change
Correct Answer:
A - IgA nephropathy
Treatment:
300
Clinical Vignette:
70M with memory issues, getting lost, repeating questions, poor recall.
Question: What is the most likely diagnosis? Treatment?
A. Frontotemporal dementia
B. Lewy body dementia
C. Alzheimer’s
D. Vascular dementia
Correct Answer:
C - Alzheimer's disease
Treatment:
300
Clinical Vignette:
28M with hemoptysis, hematuria, and linear IgG on kidney biopsy.
Question: What is the most likely diagnosis? Treatment?
A. Goodpasture
B. GPA
C. PE
D. Post-strep GN
Correct Answer:
A - Goodpasture syndrome
Treatment:
300
Clinical Vignette:
6F with itchy rash, vesicles on erythematous base in different stages.
Question: What is the most likely diagnosis? Treatment?
A. Measles
B. Rubella
C. Varicella
D. Scarlet fever
Correct Answer:
C - Varicella (chickenpox)
Treatment:
300
Clinical Vignette:
25M with episodes of sweating, palpitations, and tremor relieved by eating.
Question: What is the most likely diagnosis? Treatment?
A. Insulinoma
B. Glucagonoma
C. Somatostatinoma
D. Zollinger-Ellison syndrome
Correct Answer:
A - Insulinoma
Treatment:
300
Clinical Vignette:
45M with bone pain, anemia, renal failure, and elevated protein gap.
Question: What is the most likely diagnosis? Treatment?
A. Multiple myeloma
B. Waldenstrom's
C. AML
D. Renal cell carcinoma
Correct Answer:
A - Multiple myeloma
Treatment:
400
Clinical Vignette:
45F with rest tremor, bradykinesia, and stooped posture.
Question: What is the most likely diagnosis? Treatment?
A. Parkinson’s
B. Huntington’s
C. Wilson’s
D. Essential tremor
Correct Answer:
A - Parkinson’s disease
Treatment:
400
Clinical Vignette:
35F with non-productive cough, bilateral hilar lymphadenopathy.
Question: What is the most likely diagnosis? Treatment?
A. TB
B. Sarcoidosis
C. Pneumonia
D. Bronchitis
Correct Answer:
B - Sarcoidosis
Treatment:
400
Clinical Vignette:
3M with lethargy, vomiting, hepatomegaly after aspirin use.
Question: What is the most likely diagnosis? Treatment?
A. Viral hepatitis
B. Reye syndrome
C. Liver abscess
D. Biliary atresia
Correct Answer:
B - Reyes syndrome
Treatment:
400
65M with hypercalcemia, low PTH, metastatic breast cancer history.
Question: What is the most likely diagnosis? Treatment?
A. Primary hyperparathyroidism
B. Hypercalcemia of malignancy
C. Sarcoidosis
D. Vitamin D toxicity
Correct Answer:
B - Hypercalcemia of malignancy
Treatment:
400
Clinical Vignette:
30F with SLE history, proteinuria, HTN, and edema.
Question: What is the most likely diagnosis? Treatment?
A. FSGS
B. Diabetic nephropathy
C. Lupus nephritis
D. Minimal change
Correct Answer:
C - Lupus nephritis
Treatment:
500
Clinical Vignette:
30M with multiple personality changes, aggressive outbursts, and chorea.
Question: What is the most likely diagnosis? Treatment?
A. Multiple sclerosis
B. Huntington’s
C. ALS
D. Encephalitis
Correct Answer:
B - Huntington’s disease
Treatment:
500
Clinical Vignette:
24M with sudden onset dyspnea during basketball, hyperresonance on exam.
Question: What is the most likely diagnosis? Treatment?
A. Hemothorax
B. Asthma
C. Spontaneous pneumothorax
D. PE
Correct Answer:
C - Spontaneous pneumothorax
Treatment:
500
Clinical Vignette:
7M with petechiae after viral illness, low platelets on labs.
Question: What is the most likely diagnosis? Treatment?
A. Leukemia
B. ITP
C. DIC
D. HSP
Correct Answer:
B - Immune thrombocytopenic purpura (ITP)
Treatment:
500
Clinical Vignette:
40M with enlarged jaw, hands, feet. Elevated IGF-1 and GH levels.
Question: What is the most likely diagnosis? Treatment?
A. Acromegaly
B. Gigantism
C. Marfan syndrome
D. Cushing’s
Correct Answer:
A - Acromegaly
Treatment:
500
Clinical Vignette:
55F with schistocytes, thrombocytopenia, renal dysfunction, neuro signs.
Question: What is the most likely diagnosis? Treatment?
A. TTP
B. ITP
C. DIC
D. HIT
Correct Answer:
A - Thrombotic thrombocytopenic purpura (TTP)
Treatment:
